误诊为线状IgA大疱性皮病的系统性红斑狼疮  

Bullous systemic lupus erythematosus misdiagnosed as linear IgA bullous dermatosis:a case report

作　　者：王博[1] 陈喜雪[1] 杨海珍[1] 杨淑霞[1] 涂平[1] 

机构地区：[1]北京大学第一医院皮肤性病科,北京100034

出　　处：《临床皮肤科杂志》2010年第10期640-642,共3页Journal of Clinical Dermatology

摘　　要：报告1例误诊为线状IgA大疱性皮病的系统性红斑狼疮(SLE)。患者女。24岁,颈部、肩部环形分布水疱2个月,皮损组织病理表现为表皮下疱,真皮乳头及中层血管、毛囊周围以中性粒细胞为主的炎性浸润,直接免疫荧光检查见基膜带IgA(+)、IgG(+)线状沉积,初步诊断为线状IgA大疱性皮病。但此后实验室检查发现该患者外周血白细胞计数低、贫血、低蛋白血症、肝功能轻度异常,遂做相关检查,最后确诊为SLE。A case of a 24-year-old female presented with blisters which were distributed in annular form. Histopathologic examination showed a subepidermal blister with prominent neutrophil infiltrate with lymphocytes in the papillary dermis, perivascular and periadnexal locations. Direct immunofluorescence showed continuous linear deposits of IgA and IgG at the basement membrane zone. A diagnosis of linear IgA bullous dermatosis was made. Laboratory studies showed lencocytopenia, anemia, low albumin levels and rise of transaminases. Further examinations are consistent with the diagnosis of systemic lupus erythematosus.

关 键 词：线状IGA大疱性皮病 系统性红斑狼疮 

分 类 号：R593.24[医药卫生—内科学]