中脑导水管周围灰质内注射抗阿片肽血清对神经降压素增强电针镇痛的影响  

EFFECT OF ANTIOPIOID PEPTIDE SERA ON THE ENHANCEMENT OF ELECTROACUPUNCTURE ANALGESIA INDUCED BY NEUROTENSIN IN PAG OF RATS

作　　者：白波[1,2] 王宏[1,2] 刘文彦[1,2] 宋朝佑[1,2] 

机构地区：[1]济宁医学院神经生理研究室 [2]第二军医大学神经生物学教研室

出　　处：《生理学报》1999年第2期224-228,共5页Acta Physiologica Sinica

摘　　要：本工作以钾离子透入引起大鼠甩尾反应作为痛反应指标，观察纳洛酮（ＮＸ）和抗阿片肽血清对大鼠中脑导水管周围灰质（ＰＡＧ）内微量注射神经降压素（ＮＴ）增强电针镇痛作用的影响。结果显示：（１）ＰＡＧ内微量注射ＮＴ后，大鼠电针镇痛效应明显提高；（２）ＰＡＧ内注射大剂量ＮＸ，可以显著减弱ＮＴ增强电针镇痛效应；（３）ＰＡＧ内微量注射抗甲脑啡肽血清和抗β内啡肽血清后，ＮＴ增强电针镇痛的作用明显降低；而ＰＡＧ内微量注射抗强啡肽Ａ１１３血清，对于ＮＴ增强电针镇痛的作用并无明显影响。提示：ＰＡＧ内ＮＴ在针刺镇痛过程中发挥重要作用，ＮＴ增强电针镇痛的作用与甲脑啡肽和β内啡肽有较密切的关系。With the use of potassium iontophoresis induced tailflick for measuring the pain threshold, the effects of injecting neurotensin (NT), naloxone (NX), antimetenkephalin serum (AMEKS), antiendorphin serum (AEPS) and antidynorphin A113 serum (ADYNS) into periaqueductal gray (PAG) on electroacupuncture (EA) analgesia in rats were investigated. NT administration enhanced EA analgesia remarkably. Preinjection of NX, AMEKS and AEPS into PAG could significantly attenuate the enhancement of EA analgesia induced by NT , but not by administration of ADYNS. The results indicate that NT in PAG is responsable for the enhancement of EA analgesia. The effect of NT may be partly mediated by metenkephalin and endorphin.

关 键 词：神经降压素 中脑导水管 灰质 电针 镇痛 脑啡肽 

分 类 号：R338.3[医药卫生—人体生理学]