钯/Dabco体系催化芳基膦酸酯的合成  

Study on the Palladium/Dabco-Catalyzed Synthesis of Arylphosphonates

作　　者：朱茂根[1] 沈栋国[1] 叶柳[1] 徐广宇[1] 

机构地区：[1]湖南师范大学化学化工学院,中国长沙410081

出　　处：《湖南师范大学自然科学学报》2010年第3期57-61,共5页Journal of Natural Science of Hunan Normal University

基　　金：国家自然科学基金资助项目(2062010);湖南师范大学优秀青年人才计划资助项目

摘　　要：研究了Dabco作为高活性配体促进钯催化卤代芳烃与亚磷酸二乙酯合成芳基膦酸酯的反应.在110～115℃下,以Pd(OAc)2为催化剂,Dabco为配体,K2CO3为碱,丙酮为溶剂的优良反应体系下,生成芳基膦酸酯,净产率可达88%.本体系尤其对芳杂环膦酸酯的合成产率较高.The palladium catalyzed cross coupling of aryl halide with diethyl phosphate using Dabco as ligand to synthesize arylphosphonate was investigated in this paper.The arylphosphonates were obtained with isolated yield up to 88% under the the optimized reaction condition involving Pd（OAc）2 as a catalyst,Dabco as a ligand,acetone as a solvent,K2CO3 as a base at 110～115 ℃.It was noted that this protocol gave heteroaromatic phosphonates in good yields.

关 键 词：钯 催化 交叉偶联反应 芳基膦酸酯 芳杂环膦酸酯 

分 类 号：O627.51[理学—有机化学]