银杏叶总黄酮对脑、心缺氧的保护作用  

proteive effects of TFG against cerebral and myocardial anoxia in mice.

作　　者：章家胜[1] 陈志武[1] 赵维中[1] 岑德意[1] 方明[1] 

机构地区：[1]安徽医科大学药理教研室

出　　处：《中国中医基础医学杂志》1999年第6期25-26,共2页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的研究银杏叶总黄酮对脑、心缺氧的保护作用。方法小鼠脑、心缺氧模型分别采用断头和挟闭气管术制备，一氧化氮（ＮＯ）含量用ｇｒｅｅｎ法测定，丙二醛（ＭＤＡ）含量用ＴＢＡ法测定。结果银杏叶总黄酮２５、５０、１００ｍｇｋｇ－２显著延长夹闭气管后小鼠心电图时间和断头喘气时间，并呈量效关系，在２５－１００ｍｇｋｇ－１范围内，银杏叶总黄酮显著降低脑、心组织中ＭＤＡ和ＮＯ含量。结论银杏叶总黄酮对脑、心缺氧有显著保护作用，其作用可能与抑制膜脂质过氧化及减少ＮＯ有关。ATM: To study the protective effects of TFG against cerebral and myocardial anoxia. METHODS:The cerbral and myocardial anoxic models in mice wear made by means of Cutting head and clamping trachea respectively. The nitric oxide (NO) content was measured with green method. The TBA method was used to measured the malondialhyde (MDA) content. RESULTS:TFG 25, 50, 100mg·kg -1 markedly amd dose dependently prolonged the EEG tine after clamping trachea and the grspimg tine induced by cutting head. 25 100 mg·kg -1 TFG significcantiy roduced the MDA and No contents in the myocardium and cerebrumof mice. CONCLLUSION:TFG has protective effects against myocardial and cerebral anoxia via attenuating lipid peroxidation and No.

关 键 词：银杏叶总黄酮 脑缺氧 心脏缺氧 保护 

分 类 号：R285.5[医药卫生—中药学] R277.733.1[医药卫生—中医学]