血红素加氧酶/一氧化碳系统对家兔动脉粥样硬化发病的影响  

Influence of Heme Oxygenase/Carbon Monoxide System on Atherosclerotic Process in Rabbits

作　　者：徐少平[1] 李鲁光[1] 程友琴[1] 唐朝枢[1] 沙鸥[1] 余燕秋[1] 

机构地区：[1]北京军区北京总医院心内科

出　　处：《中国动脉硬化杂志》1999年第2期114-116,共3页Chinese Journal of Arteriosclerosis

基　　金：军队‘九.五’医药卫生科研基金

摘　　要：为探讨血红素加氧酶／一氧化碳系统对动脉粥样硬化发病的影响，采用高胆固醇饮食建立了动脉粥样硬化家兔模型，并检测了血清总胆固醇、血浆氧化型低密度脂蛋白浓度及主动脉血红素加氧酶活性、一氧化碳生成量和主动脉内膜斑块面积。结果显示，高胆固醇饮食显著升高血清总胆固醇及血浆氧化型低密度脂蛋白浓度，血红素加氧酶活性及一氧化碳生成量分别较正常组降低４０％及３０％（Ｐ＜０．０１），主动脉斑块面积达４２．６％±９．２％；血红素Ｌ赖氨酸盐恢复了一氧化碳生成量（Ｐ＜０．０１），斑块面积减少至２８．４％±８．１％（Ｐ＜０．０５）。以上提示，动脉粥样硬化家兔主动脉血红素加氧酶／一氧化碳系统活性显著受损，血红素Ｌ赖氨酸盐通过恢复主动脉一氧化碳生成量而在一定程度上抑制动脉粥样硬化进展。Aim To investigate the influence of aortic heme oxygenase/carbon monoxide (HO/CO) system on atherosclerosis induced by high cholesterol diet in rabbits. Methods Male New Zealand white rabbits were divided into three groups in random: normal group,cholesterol group and heme group. Serum total cholesterol(TC) and plasma oxidized low density lipoprotein(ox LDL) levels were detected. After 10 weeks, the aorta were harvested for assessment of HO activity, CO production and area of intima lesions. Results Compared with normal group, serum TC and plasma ox LDL levels elevated markedly in cholesterol group. Aortic HO activity and CO production decreased about 40% and 30% respectively( P<0.01). Intima lesions increased to 42.6%±9.2%. Compared with cholesterol group, administration of heme L lysinate did not altered serum TC and plasma ox LDL levels, but restored CO production(P<0.01),inhibited aortic intima lesion formation (28.4%±8.1% vs. 42.6%±9.2%, P<0.05). Conclusion The activity of aortic HO/CO system is impaired markedly in atherosclerotic rabbits induced by cholesterol diet. Heme L lysinate inhibits atherosclerotic progression in some degree by restoring CO elaboration.

关 键 词：动脉粥样硬化 血红素加氧酶 一氧化碳 病理学 

分 类 号：R543.502[医药卫生—心血管疾病]