辛伐他汀对冠心病患者低密度脂蛋白氧化修饰及血小板活化状态的影响  

The Influnce of the Simvastatin on Serum Low Density Lipoprotein Oxidation and Platelet Activation in Coronary Artery Disease Patients

作　　者：杨志明[1] 肖传实[1] 边云飞[1] 梁树芬[1] 王凤芝[1] 王友桂[1] 

机构地区：[1]山西医科大学附属第二医院心内科

出　　处：《中国动脉硬化杂志》1999年第2期161-163,共3页Chinese Journal of Arteriosclerosis

摘　　要：为观察辛伐他汀对冠心病患者低密度脂蛋白氧化修饰及血小板活化状态的影响，选择冠心病患者和正常对照者各３８例，以血浆氧化型低密度脂蛋白浓度作为脂蛋白氧化修饰的指标，血小板α颗粒膜蛋白、血栓素Ｂ２作为血小板活化状态的指标，比较冠心病患者服用辛伐他汀前后氧化型低密度脂蛋白、血小板α颗粒膜蛋白和血栓素Ｂ２的变化及与高密度脂蛋白胆固醇的关系。结果发现，冠心病患者治疗后血浆高密度脂蛋白胆固醇浓度显著升高，血浆氧化型低密度脂蛋白、血小板α颗粒膜蛋白及血栓素Ｂ２浓度明显降低，但仍未达到正常组水平。直线相关分析显示，氧化型低密度脂蛋白与血小板α颗粒膜蛋白及血栓素Ｂ２之间呈显著正相关。结果提示，辛伐他汀治疗后可显著提高高密度脂蛋白胆固醇水平，而有效抑制低密度脂蛋白的氧化修饰及血小板活化，本研究还揭示了动脉粥样硬化脂质浸润学说与血栓学说之间存在的部分内在联系。Aim To investigate the influnce of simvastatin on serum LDL oxidation and platelet activation in CAD patients. Methods 38 CAD patients and 38 normal subjects were enrolled. The serum level of ox LDL、 TXB 2 and the levels of alpha granule membrane protein (GMP 140) on the surface of platelet were measured before and after the simvastatin treatment four weeks. The relationship between ox LDL、 GMP 140、 TXB 2 and HDL was analysed. Results The level of serum HDL was significantly increased in CAD patients group after simvastatin treatment four weeks. Serum ox LDL、TXB 2 and the level of GMP 140 were decreased significantly after treatment although still below the normal level.The positive correlation was found between ox LDL and GMP 140、 TXB 2. Conclusion The study confirms that simvastatin treatment may increase serum HDL and by increasing HDL, it may effectively refrain the LDL oxidation and platelet activity. It also reveals that there being a partial relation between the atherosclerotic lesions and the thrombogenicity during atherosclerotic progresion.

关 键 词：辛伐他汀 低密度脂蛋白 冠心病 血小板 

分 类 号：R541.405[医药卫生—心血管疾病]