不同饮酒量对心血管内皮功能及炎性因子的影响  

Effects of different quantity of alcohol drinking on cardiovascular endothelial function and inflammatory factor

作　　者：蔡久英[1] 高薇[1] 徐兆龙[1] 李鑫[1] 

机构地区：[1]辽宁医学院附属第一医院心内科,辽宁锦州121001

出　　处：《中国急救医学》2010年第9期829-831,共3页Chinese Journal of Critical Care Medicine

基　　金：辽宁省教育厅高等学校科研基金资助项目（No.2009A446）

摘　　要：目的 探讨不同饮酒量对心血管内皮功能及炎性因子的影响.方法 从有10～20年饮酒史及不饮酒的健康体检者中随机选择347例,按照饮酒量的不同分为四组,即饮白酒7盎司（204 mL）/d,或啤酒18盎司（522 mL）/d,或红葡萄酒6盎司（171 mL）/d者为低量饮酒组（A组）;饮白酒12盎司（336 mL）/d,或啤酒24盎司（706 mL）/d,或红葡萄酒8盎司（208 mL）/d 者为中量饮酒组（B组）;饮白酒15盎司（420 mL）/d,或啤酒27盎司（783 mL）/d,或红葡萄酒12盎司（332 mL）/d者为高量饮酒组（C组）;非饮酒组（D组）.检测所有入选者的非对称-甲基精氨酸（ADMA）、血浆内皮素-1（ET-1）、肿瘤坏死因子（TNF-α）、一氧化氮（NO）和白细胞介素-6（IL-6）等指标.结果 D组与A组相比,上述5项指标改变差异无统计学意义（P〉0.05）;C组与A组、B组相比,上述5项指标改变差异有统计学意义（P〈0.01,〈0.05）;B组与A组上述指标有不同程度的改变,但差异无统计学意义（P〉0.05）.结论 大量饮酒损害心血管内皮功能,炎性指标明显升高.血管内皮损伤及炎性因子的升高,共同促进动脉粥样硬化的形成和发展.最终导致心血管疾病的发生、发展.关于高剂量饮酒后发生心血管内皮损伤的机制,还有待于进一步的探讨.Objective To discuss the effects of the different quantity of alcohol drinking on the cardiovascular endothelial function and the inflammatory factor. Methods 347 cases selected randomly including the drinker with 10 - 20 years drinking history and healthy volunteers were divided into 4 groups according to different quantity of alcohol drinking： group A, the white liquor 7 ounces （204 mL）/day, or the beer 18 ounces （522 mL）/day, or the red wine 6 ounces （ 171 mL）/day to drink; group B, the white liquor 12 ounces （336 mL）/day, or the beer 24 ounces （706 mL）/day, or the red wine 8 ounces （208 mL） / day to drink; group C, the white liquor 15 ounces （420 mL）/day, or the beer 27 ounces （783 mL）/day, or the red wine 12 ounces （332 mL）/day to drink; group D, the control group, did not drink. Asymmetrical - methyl arginine, endothelin - 1 （ ET - 1 ）, tumor necrosis factor （TNF） -or, nitrogen monoxide （NO） and interleukin - 6 （IL-6） and so on were examined in all 347 cases. Results The group D compared with group A, and group B comparecI with group A, the results showed there were no statistical differences in 5 parameters （ P 〉 O. 05 ）. Group C compared with group A, and group C compared with group B, the results showed there were statistical differences in 5 parameters （ P 〈 0. 01 ） or （ P 〈 0. 05 ） respectively. Conclusion Alcohol drinking is harmful to the cardiovascular endothelial function, the inflammatory markers elevate obviously, which causes atherosclerosis formation and development.

关 键 词：饮酒 血管内皮功能 炎性因子 内皮素-1(ET-1) 肿瘤坏死因子-α(TNF-α) 一氧化氮(NO) 白细胞介素-6(IL-6) 

分 类 号：R541.4[医药卫生—心血管疾病]