透皮促进剂对消旋延胡索乙素体外经皮渗透的影响  

Influence of Penetration Enhancers on in Vitro Transdermal Permeation of D,L-Tethrahydropalmatine

作　　者：钱励[1] 马臻[1] 张望刚[1] 王俏[1] 

机构地区：[1]浙江省医学科学院药物研究所,杭州310013

出　　处：《中国药学杂志》2010年第19期1484-1488,共5页Chinese Pharmaceutical Journal

基　　金：浙江省科技计划项目(2007F30013)资助

摘　　要：目的考察不同透皮促进剂对消旋延胡索乙素体外经皮渗透的影响。方法采用Valia-Chien双室渗透扩散池,以大鼠离体皮肤为渗透屏障,用高效液相色谱法对延胡索乙素进行含量测定,考察月桂氮酮、丙二醇及两者按不同比例混合对消旋延胡索乙素的促透效果。结果月桂氮酮、丙二醇单独使用均对延胡索乙素有促透作用,月桂氮酮促透效果较强,8%月桂氮酮促透效果最好,平均渗透速率达到12.397μg.cm-2.h-1。单用丙二醇时,15%丙二醇促透效果较好,平均渗透速率为3.142μg.cm-2.h-1。两者合用促透效果始终小于月桂氮酮单独使用时效果,且与单用8%Azone有极显著性差异(P<0.01)。结论月桂氮酮浓度为8%时消旋延胡索乙素饱和溶液体外渗透具有最大促透效果,月桂氮酮和丙二醇合用并未体现协同作用。OBJECTIVE To study the effect of penetration enhancers on tbe hansdermal permeation in vitro of D,L-Tethrahydrop- almatine （D,Z-THP） through ral skin. METHODS Azone and propylene glycol （PC） as chemical pencotration enhancers were applied alone or jointly to investigate the skin pemeation rates of D,L-THP The skin permeation profiles were exaluated by Valian-Chien permeation cells with isolated rat skin. HPLC-UV melhod was estahlished to determine the eoneenlradon of D,L-TtlP in samples. RESULTS 8% Azone alone was observed to be the optimal penetration enhancer with the maximal penetration rate of 12. 397 μg ·cm^-2 · h^-2 . The highe.st penelradma rate of PG alone was achieved at 15% with the rale of 3. 142 μg · cm^2 · h^-1 . The penetration potency of agone combined with PG was less effective than that of Azone azone. CONCLUSION 8% Azone was effer-tive on trans- dermal petmeation tff D,L-THP in vitro. There is no synergislie effect to be found found Azone eomlfined with various eoueentrations of PG.

关 键 词：消旋延胡索乙素 经皮渗透 促进剂 月桂氮酮 丙二醇 

分 类 号：R944[医药卫生—药剂学]