卡马西平引起重症药疹2例及相关基因HLA-B^＊1502的检测  

Carbamazepine-Induced Severe Epispasis in Two Patients and Their HLA-B*1502 Allele Detection

作　　者：王丽彬[1] 陈斌[2] 孙蔚凌[2] 欧宁[1] 

机构地区：[1]南京医科大学第一附属医院药剂科,南京210029 [2]南京医科大学第一附属医院皮肤科,南京210029

出　　处：《中国药学杂志》2010年第19期1513-1515,共3页Chinese Pharmaceutical Journal

基　　金：江苏省临床药学研究基金(L07003)

摘　　要：目的探讨卡马西平引起重症药疹与HLA-B*1502等位基因是否存在相关性。方法收集因服用卡马西平引起严重皮疹的患者外周静脉血,利用引物序列特异性PCR(Polymerase chain reaction-sequence specific primer,PCR-SSP)检测HLA-B*1502等位基因。结果 2例患者的HLA-B*1502等位基因均为阳性。结论卡马西平引起重症药疹可能与HLA-B*1502等位基因存在相关性,建议必要时在用药前给予患者进行血液基因检测,以最大程度保障患者用药安全。OBJECTIVE To investigate the relationship between HLA-B＊1502 allele and severe epispasis induced by carbamazepine. METHODS The blood of patients with severe epispasis induced by carbamazepine was collected and the HLA-B＊1502 allele was determined by PCR-SSP. RESULTS HLA-B＊1502 allele of the two patients in this research were all positive. CONCLUSION It is necessary to detect HLA-B＊1502 allele before prescribing carbamazepine.

关 键 词：卡马西平 重症药疹 HLA-B＊1502 

分 类 号：R994.11[医药卫生—毒理学]