氟比洛芬酯对肝硬化患者术后镇痛效果和凝血功能的影响  

Effects of flurbiprofen axetil on postoperative analgesia and blood coagulation in patients with liver cirrhosis

作　　者：张建[1] 张维峰[1] 廖建梅[1] 王佳[1] 殷国平[1] 

机构地区：[1]东南大学附属南京市第二医院麻醉科,210003

出　　处：《临床麻醉学杂志》2010年第9期761-763,共3页Journal of Clinical Anesthesiology

摘　　要：目的观察氟比洛芬酯用于肝硬化患者术后镇痛效果和凝血功能的影响。方法选择90例肝炎后肝硬化拟行脾切断流术患者,随机均分为A、B、C组。A组于手术开始前10min静注氟比洛芬酯50mg,B组于术毕静注氟比洛芬酯50mg,C组于术毕静注生理盐水。三组患者术后均行静脉自控镇痛(PCIA),采用VAS对术后4、8、12、24、48h内疼痛进行评价,检测术前、术后即刻、24、48h凝血酶原时间(PT)、激活部分凝血酶原时间(APTT)、纤维蛋白原(Fib)、血小板计数(Plt)及平均血小板体积(MPV)。结果术后VAS评分A、B两组明显低于C组,A组低于B组(P<0.05);三组术前、术后即刻、24、48h凝血功能组间及组内比较差异均无统计学意义,结论氟比洛芬酯术后镇痛效果满意,对患者凝血功能无影响,可安全用于肝硬化行脾切断流术患者术后镇痛。Objective To observe the effects of flurbiprofen axetil （FA） on postoperative analgesia and blood coagulation in patients with liver cirrhosis. Methods Ninety patients with liver cirrhosis were randomly divided into groups of A B and C with 30 cases each. Group A received FA 50 mg Ⅳ. at 10 min before surgery,which was injected at the end of operation in group B. Group C was given normal saline instead of FA as the control. Three groups were given postoperative patientcontrolled intravenous analgesia（PCIA）. The postoperative analgesic effect was assessed by VAS at 4, 8,12,24 and 48 h after surgery. PT, APTT, Fib, Pit and MPV were recorded before, at the end of operation and at 24 and 48 h after surgery. Results VAS score in groups of A and B were significantly less than that in group C（P〈0.05） ,which was less in group A than that in group B（P〈0. 05）. There were no statistical differences in the blood coagulation examinations among three groups. Conclusion FA injection has satisfying Postoperative analgesia with FA injection is effective without significant adverse effect on blood coagulation in patients with liver cirrhosis.

关 键 词：氟比洛芬酯 术后镇痛 凝血功能 

分 类 号：R614[医药卫生—麻醉学]