小剂量纳洛酮对舒芬太尼术后镇痛及不良反应的影响  

Effect of low dose naloxone on analgesia and side effects of postoperative sufentanil

作　　者：张葆[1] 张卫东[1] 恽伟方[1] 李立[1] 

机构地区：[1]南京医科大学附属常州第二人民医院麻醉科,常州市213003

出　　处：《临床麻醉学杂志》2010年第9期775-776,共2页Journal of Clinical Anesthesiology

摘　　要：目的观察小剂量纳洛酮对舒芬太尼术后静脉自控镇痛(PICA)效果及不良反应的影响。方法选择全麻术后行静脉自控镇痛患者100例,随机分为舒芬太尼复合纳洛酮组(A组)和舒芬太尼组(B组),每组50例。术后24h进行VAS疼痛评分,并记录不良反应。结果两组镇痛效果差异无统计学意义;但A组恶心、呕吐及瘙痒发生率明显低于B组(P<0.05)。结论小剂量纳洛酮可有效减少舒芬太尼术后镇痛不良反应发生率,但并不影响其镇痛效果。Objective To observe the effects of low dose naloxone on the analgesia and side effects of postoperative sufentanil. Methods One hundred patients undergone general anesthesia and given patient-controlled intravenous analgesia（PCIA） were randomly assigned into two groups with 50 cases each. Group A was given sufentanil plus low dose naloxone for PCIA and group B was given sufentanil only. VAS pain scoring was performed during the first 24 h after surgery. The side effects were recorded as well. Results There was no signifieant difference in pain scores between two groups. But the incidence of nausea, vomiting and pruritus in group A was significantly lower than that of group B（P〈0.05）. Conclusion Low dose naloxone can effectively reduce the incidence of side effects of PCIA with sufentanil without affecting on analgesic efficacy.

关 键 词：术后镇痛 纳洛酮 舒芬太尼 

分 类 号：R614[医药卫生—麻醉学]