毛细管电泳-电化学发光测定人尿中的氟哌啶醇  

Determination of Haloperidol in Human Urine by Capillary Electrophoresis Electrochemiluminescence

作　　者：康艳辉[1,2] 朱廷春[3] 何红梅[2] 邓必阳[1] 

机构地区：[1]广西师范大学化学化工学院,广西桂林541004 [2]河北工程大学医学院,河北邯郸056002 [3]邯郸学院化学系,河北邯郸056005

出　　处：《广西师范大学学报（自然科学版）》2010年第3期42-45,共4页Journal of Guangxi Normal University:Natural Science Edition

基　　金：国家自然科学基金资助项目(20965001);广西自然科学基金资助项目(2010GXNSFA013051)

摘　　要：建立毛细管电泳电化学发光法测定氟哌啶醇的新方法.考察了工作电极电位、磷酸盐缓冲液浓度及其pH值等对氟哌啶醇测定的影响.在优化实验条件下,氟哌啶醇浓度线性范围为0.01～10 mg·L^-1,检出限（3σ）为3.5μg·L^-1;相对标准偏差为1.6%（3.0 mg·L^-1,n=11）.利用该法测定了人尿加标后氟哌啶醇的含量,回收率为95.0%～99.5%.A novel method of capillary electrophoresis （CE） with tris （2,2＇-bipyridyl）ruthenium （ I ） electrochemiluminescence （ECL） detection has been developed for the determination of haloperidol in human urine. The parameters such as work electrode potential,concentration and pH of phosphate buffer solution on effect of ECL intensity of haloperidol were investigated. Under optimized conditions,haloperidol concentration was linear with ECL peak area in the range of 0. 01 - 10 mg·L^-1. The detection limit （3a） for haloperidol was 3. 5 mg·L^-1,and the RSD was 1.6% for 3.0 mg·L^-1 haloperidol （n=11）. The recoveries were between 95.0% and 99.5%.

关 键 词：毛细管电泳 电化学发光 氟哌啶醇 钌联吡啶 

分 类 号：O657.8[理学—分析化学]