原发性高血压患者中医辨证分型与血管紧张素Ⅱ-1型受体基因多态性相关性研究  

Correlation between TCM pattern types and AT1R gene polymorphism in patients with essential hypertension

作　　者：董昌武[1] 董梅[1] 邢齐树[1] 黄开泉[1] 周雪梅[1] 陈雪功[1] 

机构地区：[1]安徽中医学院,安徽230038

出　　处：《北京中医药大学学报》2010年第9期636-640,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：安徽省科技厅自然基金项目(No.7020303078);安徽省教育厅自然基金项目(No.kj2007A036)

摘　　要：目的探讨原发性高血压不同中医证型与血管紧张素Ⅱ-1型受体(AT1R)基因多态性分布的相关性。方法选择原发性高血压患者120例,中医辨证分型为肝火旺盛型、阴虚阳亢型、阴阳两虚型、痰湿壅盛型,另选取正常对照组30例,采用PCR方法检测AT1R基因多态性。结果高血压组与正常对照组比较AT1R基因AC+CC基因型及C等位基因均有显著性差异(P<0.05);在中医各证型中,AT1R基因AC+CC基因型及C等位基因在阴阳两虚型与正常对照组之间有显著性差异(P<0.05),其他各证型之间及与正常对照组比较均没有显著性差异(P>0.05)。结论原发性高血压阴阳两虚型可能与AT1R基因AC+CC基因型及C等位基因相关联。Objective To discuss the correlation between TCM pattern types and the distribution of polymorphism of receptor of angiotensin Ⅱ-1（AT1R） gene in the patients with essential hypertension.Methods The patients（n=120） with essential hypertension（EH） were chosen and classified into the types of liver fire hyperactivity,yin deficiency with yang hyperactivity,dual deficiency of yin and yang,and phlegm-damp retention.Other 30 cases were included into the control group.The polymorphism of AT1R gene was detected by applying polymerase chain reaction（PCR）.Results There was a significant difference in AC＋CC genotype and C allele of AR1T gene（P0.05） between the EH group and control group.Among all TCM pattern types there was a significant difference in AC＋CC genotype and C allele of AR1T gene between the type of dual deficiency of yin and yang and normal control group（P0.05）,and there was no significant difference between other pattern types and control group（P0.05）.Conclusion The type of dual deficiency of yin and yang of essential hypertension may be correlated to AC＋CC genotype and C allele of AR1T gene.

关 键 词：原发性高血压 血管紧张素Ⅱ-1型受体基因多态性 中医辨证 

分 类 号：R259.441[医药卫生—中西医结合]