胺碘酮与索他洛尔治疗心房颤动的荟萃分析  

Meta Analysis of Atrial Fibrillation Treated by Amiodarone and Sotalol

作　　者：高植明 

机构地区：[1]珠海市人民医院,519000

出　　处：《中国医药指南》2010年第29期189-190,共2页Guide of China Medicine

摘　　要：目的探讨胺碘酮与索他洛尔在治疗心房颤动上的有效性、安全性。方法利用计算机检索中国全文期刊数据库中关于胺碘酮与索他洛尔治疗心房颤动的对照研究,由2名研究员独立进行文献质量评估等并进行相关荟萃分析。结果共纳入5个随机对照研究,411例患者。荟萃分析结果表明,胺碘酮、索他洛尔对心房颤动的治疗转复率无显著性差异;胺碘酮、索他洛尔的不良反应发生率未见统计学差异。结论 从药物的安全性、耐受性、不良反应考虑,胺碘酮索他洛尔均可作为治疗心房颤动的首选用药。Objective To evaluate the effectiveness and security of using amiodarane versus sotalol for the treatment of atrial fibrillation.Methods Using the computer retrieval about amiodarone and sotalol for the treatment of atrial fibrillation in CNKI.Quality assessment documents and relevant Meta analysis are done by two reviewers independently.Results A total of five randomized study, 411 patients.Meta analysis results show that the amiodarone, sotalol treatment of atrial fibrillation rate of whom no significant differences, Amiodarone, he has not seen the incidence of aderse statistical differences.Conclusion The safety and tolerability from drugs, adverse reactions, amiodarone sotalol can be used as the preferred treatment of atrial fibrillation.

关 键 词：胺碘酮 索他洛尔 心房颤动 荟萃分析 

分 类 号：R541.7[医药卫生—心血管疾病]