白细胞介素-6水平与病毒性肝炎的关系  

Relationship between the Level of IL-6 and Viral Hepatitis

作　　者：张燕[1] 印建[1] 

机构地区：[1]扬州大学医学院附属医院传染科,225001

出　　处：《中西医结合肝病杂志》1999年第3期3-4,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨白细胞介素-6(IL-6)水平与病毒性肝炎的关系。方法:采用ELISA法对85例病毒性肝炎患者进行IL-6检测。结果:各型肝炎患者IL-6水平均显著高于健康对照(P<0.01),且随着肝炎病程加重而升高,尤以重型肝炎明显,在急性、慢性、重型肝炎的急性期或活动期时IL-6水平与总胆红素呈显著正相关,HBV-DNA阳性者IL-6水平明显高于HBV-DNA阴性者(P<0.01)。结论:IL-6在肝细胞损伤机制中发挥一定作用,IL-6水平越高,肝损害越重,IL-6高水平持续存在,可促进肝炎的慢性化和纤维化发展。同时,IL-6水平与病毒复制有关。Aim: To probe the relationship between the level of IL-6 and viral hepatitis. Methods: ELISA method was taken for detecting the level of IL-6 in serum in 85 patients with viral hepatitis. Result: The levels of IL-6 in patients with viral heaptitis were higher than normal group(P<0.01),and were higher while the patients were severe, especially for severe hepatitis, and in HBV-DNA positive patients were higher than HBV-DNA negative (P<0. 01). The level of IL-6 have positive relation to total bilirubin in acute hepatitis,chronic hepatitis,the active and acute period of severe hepatitis. Conclusion: IL-6 takes effect in the damage mechanism of liver cell. Higher the levels of IL-6, more severe hepatic damage. With the higher levels of IL-6.it may promote chronicity of hepatitis and occuring on hepatocirrhosis. It reminds that the levels of IL-6 have relation with the copy of virus.

关 键 词：病毒性肝炎 白细胞介素-6 病理学 肝纤维化 

分 类 号：R512.602[医药卫生—内科学] R575.202[医药卫生—临床医学]