2型糖尿病粗神经纤维损伤血清空腹C肽水平变化  

Blood serum fasting C peptide, variation of large nerve fiber neuropathy

作　　者：周怡昆[1] 张永红[1] 赵仁华[1] 张虹[1] 苏恒[1] 马杉[1] 薛元明[1] 

机构地区：[1]云南省第一人民医院（昆明医学院附属昆华医院）内分泌代谢科,昆明650032

出　　处：《中国临床实用医学》2010年第10期23-24,共2页China Clinical Practical Medicine

摘　　要：目的研究2型糖尿病粗细神经纤维损伤血清空腹c肽水平变化。方法应用振动感觉分析仪及定量感觉障碍分析检测仪对1118例2型糖尿病患者行振动感觉，冷感觉，温感觉，冷痛觉，热痛觉检测，同时行空腹血清C肽水平检测。结果粗神经纤维损伤的2型糖尿病患者空腹血清C肽水平为（0．56±0．49）nmol／L，明显低于细神经纤维损伤的空腹血清C肽水平（0．64±0．58）nmol／L和无感觉神经纤维损伤的空腹血清C肽水平（0．72±0．49）nmol／L，P〈0．05。结论低空腹c肽水平与粗有髓神经纤维损伤明显相关。Objective To study the blood serum fasting C peptide, variation of damaged large bets. Methods 1118 2 type diabetic patients were detected vibration perception, and sensation of cold,warmth,heat- induced pain, cold-induced pain by using vibration perception test method （VSA-3000）and quantitative analysis of detection of sensory disturbance TSA-2001, at the same time, to measure serum fasting C peptide. Results Serum fasting C peptide, mean level of damaged large her group was（ 0. 56 ±0. 49 ）nmolfl which was lower than that of damaged small fiber group （ 0. 64 ± 0. 58 ） nmol/1 and that of normal sensation group （ 0. 72 ± 0. 49 ） nmol/ L. P 〈 0. 05. Conclusion lower serum fasting C peptide has relationship with large nerve fiber neuropathy.

关 键 词：2型糖尿病 粗神经纤维损伤 血清空腹C肽水平 

分 类 号：R587.2[医药卫生—内分泌]