静脉泵入地尔硫卓治疗难治性不稳定型心绞痛的临床观察  

Clinical observation of infusion of intravenous diltiazem in treatment of refractory unstable angina

作　　者：吴业新[1] 张素花[1] 

机构地区：[1]山东省淄博市临淄区人民医院心内科,255400

出　　处：《中国临床实用医学》2010年第10期30-31,共2页China Clinical Practical Medicine

摘　　要：目的探讨地尔硫卓对难治性不稳定型心绞痛的疗效和安全性。方法42例对常规抗心绞痛治疗无效的不稳定型心绞痛患者，给予静脉持续泵入地尔硫卓72h治疗。严格控制地尔硫卓的剂量。观察治疗前后心绞痛发作次数、发作时ST段压低及血流动力学指标的变化，并注意药物不良反应。结果静脉滴注地尔硫卓治疗后，心绞痛得到有效控制，总有效率90．5％。与治疗前比较，治疗后的平均心绞痛发作次数减少、每次发作持续时间缩短、发作时ST段压低程度减轻（P〈0．05）；治疗后血压、心率（P〈0．05）和收缩压×心率均明显降低（P〈0．01），未发现严重不良反应。结论地尔硫卓静脉泵入治疗难治性不稳定型心绞痛安全、有效，但需严格控制药物剂量。Objective To investigate the efficacy and safety of dihiazem to refractory unstable angina pectoris. Methods 42 unstable angina patients, who were failed to conventional anti-angina pectoris treatment, were treated with continuous infusion of intravenous diltiazem for 72 hours. Gradual titration of diltiazem was controlled. Angina attack frequency, ST segment depression and changes in blood rheologic indexes were observed before and after treatment. Results The attack of angina was effectively controlled after diltiazem treatment. The total effective rate was 90. 1%. The average attack frequency, average attack duration and depression of ST segment were significantly decreased after diltizaem treatment （ P 〈 0. 05 ）. The blood pressure, heart rate （ P 〈 0. 05 ） and the systolic blood pressure × heart rate significantly decreased（ P 〈 0. 01 ） after diltizaem treatment, without serious adverse reactions. Conclusion It was effective and safe to treat refractory unstable angina pectoris with dihizaem intravenous injection, but the dose titration should be strictly controlled.

关 键 词：难治性不稳定型心绞痛 地尔硫卓 疗效 安全性 

分 类 号：R541.4[医药卫生—心血管疾病]