甲砜霉素甘氨酸酯盐酸盐的合成研究用电导率的方法测定α-卤代羰基化合物与乌洛托品成盐反应  

A Research for Synthesis of Thiamphenicol Glycinate Hydrochloride The Urotropine Salt from Halo Carbonyl Compound wasDetermined by Electroconductivity

作　　者：孙逊[1,2] 陈纪岳[1,2] 董纪昌[1,2] 

机构地区：[1]上海医科大学有机化学教研室 [2]上海医科大学物理化学教研室

出　　处：《中国药物化学杂志》1999年第2期135-137,共3页Chinese Journal of Medicinal Chemistry

摘　　要：具有活性较强基团α卤代羰基的化合物甲砜霉素氯乙酸酯和对硝基α溴代苯乙酮都能发生Ｄｅｌéｐｉｎｅ反应，在此过程中，与乌洛托品成盐反应的前后电导率有显著的变化，因而可用电导率的测定证明其与乌洛托品形成盐；并且可利用测定电导率变化跟踪反应过程与判断反应终点．A comparatively active halo carbonyl compound,such as thiamphenical chloracetic ester and pnitrobromoacetophenone can carry out the Delepine reaction.In the intermediate process of the Delepine reaction,there are obvious differences of electroconductivity after and before forming the urotropine salt.So the urotropine salt had been confirmed by determing electroconductivity.Besides,we could also trail the reaction process and determine the reaction equilibrium.

关 键 词：卤代羰基 甲砜霉素 甘氨酸酯 电导率 成盐反应 

分 类 号：TQ465.91[化学工程—制药化工] TQ460.31