从FPN1基因筛选预测有氧耐力训练对左心室功能指标影响的分子标记  

Selecting the Genetic Markers for Response to Left Ventricular Functions for Aerobic Endurance Training from FPN1 Genetic Screen

作　　者：乌云格日勒 胡扬[2] 李燕春[2] 聂晶[3] 席翼[4] 文立[5] 

机构地区：[1]内蒙古师范大学,内蒙古呼和浩特010022 [2]北京体育大学,北京100084 [3]江西师范大学,江西南昌330027 [4]深圳大学,广东深圳518060 [5]天津体育学院,天津300381

出　　处：《体育科学》2010年第10期41-45,51,共6页China Sport Science

基　　金：科技部奥运攻关课题(2006BAK12B01)

摘　　要：目的:通过膜铁转运蛋白1(FPN1)基因多态性与有氧耐力训练后左心室功能指标训练效果的关联性分析,以期能为预测有氧耐力训练效果和制定个性化有氧耐力训练方案提供科学依据。方法:对102名中国北方平原地区健康男子进行为期18周的有氧耐力训练,使用超声心动仪测定其训练前后安静状态和递增负荷运动下的左心室结构功能指标,应用PCR-RFLP技术解析受试者FPN1基因rs1123110、rs4145237多态性。采用associationstudies with training response phenotypes方法,分析rs1123110、rs4145237多态性与训练前后左心室结构功能指标变化的关联性。结果:经18周有氧耐力训练后,rs1123110的CC型群体100W/SV和100W/SVI的增加量显著高于TT型群体、CO和COI的下降量显著大于TT和TC型群体;rs4145237的CG型群体训练前安静时CO和Re/EF的增加量显著高于其他基因型。研究表明,rs1123110的CC型和rs4145237的CG型可以作为预测部分心室功能指标训练效果的分子标记。Objective.. To study the association between polymorphism in FPN1 gene and response to left ventricular functional parameters after aerobic endurance training, in order to screen genetic markers of aerobic endurance training and provide evidence to genetic individual program. Methods： 102 health males were completed 18-weeks aerobic endurance training. Echocardiography was used to measured parameters of left ventricular functions on resting state before and after training, and incremental exercise. The genotypes were examined in SNP rs 1123110, rs 4145237 by PCR- RFLP and association between gene polymorphlsm and parameters of left ventricular function were adopted association studies with training response phenotypes. The increment of 100W/SV and 100W/SVI with CC genotype in rs1123110 were significantly higher than TT＂ genotype, and decrease in the amount of CO and COI were significantly higher than TT and TC genotype. Result： The rs1123110 and rs4145237 polymorphism of FPN1 gene can be used as genetic markers of the response to left ventrieular function to aerobic training.

关 键 词：膜铁转运蛋白1 基因多态性 训练 左心室功能 分子标记 

分 类 号：G804.7[文化科学—运动人体科学]