激光心肌血管重建术后冠脉流量变化的实验研究  

The experimental research on the change of coronary blood flow after TMLR in dogs with AMI

作　　者：陈炬[1] 郑光圃[1] 张惠忠[1] 黄洪铮[1] 熊利华[1] 张华[1] 麦嘉秉[1] 潘越江[1] 王铭辉[1] 华平[1] 

机构地区：[1]广州中山医科大学孙逸仙纪念医院心胸外科,510120

出　　处：《中国全科医学》1999年第3期178-179,共2页Chinese General Practice

基　　金：广东省自然科学研究基金!950318

摘　　要：目的观察激光心肌血管重建术（TMLR）后心肌血流量的变化，探讨TMLR的作用机制。方法18只犬随机等分为3组：A组－对照组；B组－缺血组；C组－激光组。采用连续型Nd：YAG激光行心肌打孔，光纤直径0．6mm，功率20～25W，脉冲时间0．3～0．5s，孔间距离8～10mm。LAD结扎前、结扎后30min和60min收集冠状静脉窦血计算心肌血流量。采用随机分组设计的方差分析（α＝0.05）。结果缺血组LAD结扎后心肌血流量进行性下降（P＜0．05），而激光组LAD结扎前后比较无显著性差异（P＞0．05），但结扎后明显高于缺血组（P＜0．05）。结论TMLR可迅速有效地改善心肌缺血。objective To observe the change of myocardial blood flow(MBF) after TMLR indogs with experimental AMI to detect the mechanism of TMLR. Methods 18 mongrel dogs were ran-domly divided into three groups (n= 6 in each group ), namely the control groupand the AMI group andthe TMLR group Continuous wave Nd: YAG laser was used to create the transmural channels in theischemic area, with exposed light-guided fiber of 0. 6mm in diameter; laser power 20-25 watt and 0. 3-0. 5 sec/pulse, with 8-10mm apart. Myocardial blood flow was calculated by collection of the bloodfrom the coromary sinus 0 min before the LAD ligation. 30 min and 60 min after the LAD ligation.Statistic analysis was done by rank test (α= 0. 05). Results The MBF of the AMI group kept decreas-ing after the LAD ligation (P＜0. 05), while the MBF of TMLR group did not show tistinctive differ-ences be fore or after the LAD ligation(P＜0. 05 ). but was muck higher than that of the AMI group (P＜0. 05). Conclusion The TMLR could effectively improve myocardial ischemia.

关 键 词：心肌缺血 心肌血管重建 心肌血流量 激光疗法 

分 类 号：R654.205[医药卫生—外科学] R454.2[医药卫生—临床医学]