钯催化一锅法合成2炔基苯并呋喃的研究  

Study on One-Pot Synthesis of 2-Ynyl-Benzofuran with Palladium as Catalyst

作　　者：陶李明[1] 刘文奇[1] 周芸[1] 周菊峰[1] 

机构地区：[1]湘南学院化学与生命科学系,湖南郴州423000

出　　处：《西南大学学报（自然科学版）》2010年第9期50-53,共4页Journal of Southwest University(Natural Science Edition)

基　　金：湖南省自然科学基金资助项目(08JJ3018);湖南省教育厅资助项目(08C828)

摘　　要：在三乙胺与四氢呋喃混合溶剂中,邻乙炔基苯酚与E-1,2-二碘烯烃在醋酸钯及碘化亚铜的作用下,首先在室温下反应15h,然后在100℃左右继续反应,采用一锅法合成了4种2-炔基苯并呋喃化合物,该方法条件温和且产率较好,产物结构经由NMR和MS确证.Four 2-ynyl-benzofurans were synthesized by the reaction of 2-ethynylaniline and E-1,2-diiodoalkenes in the presence of palladium （II） acetate and copper （I） iodide as the catalysts via a one-pot reaction in a triethylamine-tetrahydrofuran medium. The reaction at room temperature for 15 h and then at 100 ℃ for the remaining time gave the desired 2-ynyl-benzofurans in moderate yields under mild conditions. The structures of the product were characterized and confirmed by MS and NMR spectrum.

关 键 词：一锅法 合成 2-炔基苯并呋喃 

分 类 号：O621.3[理学—有机化学]