热休克蛋白70-2（HSP70-2）基因多态性与冠心病的相关性研究  

The association between heat-shock protein 70-2 gene ＋ 1267A/G polymorphism and coronary heart disease

作　　者：段成城[1] 陈倩[2] 郑美梅[1] 王方剑[1] 江勇[1] 潘小华[1] 董丽妍[1] 

机构地区：[1]广州医学院附属深圳沙井医院心内科,深圳518104 [2]广州医学院附属深圳沙井医院产科

出　　处：《中国医师杂志》2010年第9期1194-1197,共4页Journal of Chinese Physician

基　　金：深圳市宝安区科技局资助项目（NO：2009336）;

摘　　要：目的 探讨热休克蛋白70-2（HSP70-2）基因＋1267A/G多态性在中国汉族人群中的分布及与冠心病的相关性.方法 采用聚合酶链反应-限制性片段长度多态性技术,对汉族185例冠心病患者及149名正常人群HSP70-2基因＋1267A/G多态性,基因型及等位基因分布进行研究.结果 研究人群中存在HSP70-2基因＋1267A/G多态性,基因型符合Hardy-Weinberg平衡,冠心病患者G等位基因频率显著高于对照组（61.89%vs51.68%,P＜0.01）.Logistic回归分析得出：HSP70-2基因＋1267A/G多态性（AG＋GG）基因型是冠心病的独立危险因素,（AG＋GG）基因型比AA基因型的OR=2.031,95%CI=1.024～4.026.结论 HSP70-2基因＋1267A/G多态性与冠心病有关,G等位基因可能是汉族人群冠心病的遗传危险因素.Objective To investigate the correlation between heat-shock protein 70-2 （HSP70-2） gene＋1267A/G polymorphism and coronary heart disease （CHD） in Han Chinese population. Methods Using the method of polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） , the polymorphism and genotype and allele distribution of HSP70-2 gene ＋ 1267A/G in 185 CHD patients and 149 controls were analyzed. Results The HSP70-2 gene ＋ 1267A/G polymorphism was found in this study population.The distribution of HSP70-2 genotypes was in Hardy-Weinberg equilibrium. The frequency of G allele in CHD group was significantly higher than that in control （61.89% vs51.68%, P 〈 0. 01）. After multiple logistic regression analysis, HSP70-2 gene （GG ＋ AG） genotype was an independent risk factor of coronary heart disease. Conclusion HSP70-2 gene ＋ 1267A/G polymorphism was associated with CHD risk of Han Chinese population, the G allele might serve as a genetic risk factor of coronary heart disease.

关 键 词：HSP70热休克蛋白质类/代谢/遗传学 多态现象 遗传 冠心病/代谢/遗传学 

分 类 号：R541[医药卫生—心血管疾病]