延缓衰老相关的小分子物质研究进展  

The Research Advances in Small Molecules Related With Delaying Aging

作　　者：高凌云[1] 李国栋[1] 童坦君[1] 

机构地区：[1]北京大学医学部生物化学与分子生物学系,北京大学衰老研究中心,北京100191

出　　处：《生物化学与生物物理进展》2010年第9期932-938,共7页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展计划(973)(2007CB507400);国家自然科学基金资助项目(30973146)~~

摘　　要：筛选、研究具有延缓衰老作用的小分子物质,对于发现新的治疗衰老相关性疾病及肿瘤等的有效靶点、开发新型药物、促进人类健康具有重大的现实意义.同时更重要的是,可以这些小分子物质为切入点,对衰老、肿瘤等生命现象的具体分子机制进行深入研究,这对于分子生物学等相关生命科学研究的发展具有重要的推动作用.总结了近一二十年来发现的一些具有代表性的可延缓衰老的小分子物质,并重点论述了其作用的分子机制.Screening small molecules having anti-aging effect and researching the mechanism are of great practical significance for discovering new effective targets for treatment of age-related diseases and tumors, developing new drugs and promoting human health. What is more important is that these small molecules can be used as breakthrough points for the specific molecular mechanisms of aging, cancer and other biological phenomena via in-depth study. And this has an important role in promoting the development of molecular biology and other related life sciences. This article summarizes some representative anti-aging small molecules of the past decade or two and focuses on their molecular mechanisms.

关 键 词：衰老 SIRT1 晚期糖基化终末产物 TOR 热量限制 药物 肿瘤 

分 类 号：Q26[生物学—细胞生物学] Q5