肝脏移植急性排异与慢性排异的临床和病理分析  

Clinical and pathological analysis of acute and chronic rejection of human liver allografts

作　　者：陈嘉薇[1] 陈大志[2] 薛玉华[1] 付红[1] 陈昭民[3] 

机构地区：[1]哈尔滨医科大学第二临床医学院病理科,150086 [2]哈尔滨医科大学第二临床医学院变外科,150086 [3]哈尔滨医科大学第二临床医学院普外科,150086

出　　处：《中华肝胆外科杂志》1999年第3期161-162,共2页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的研究肝脏移植急性排异和慢性排异的临床表现及病理改变。方法观察和分析了我院２例肝移植患者术后出现急性和／或慢性排异时的临床表现，实验室检查及病理所见。结果急性排异时．ＡＳＴ和ＡＬＴ升高十分显著，而ＴＢＩＬ相对低，病理学有三个主要特征；而慢性排异时，ＴＢＩＬ。升高非常明显，ＡＳＴ和ＡＬＴ相对低，病理学有两个主要特征。结论实验室检查和病理特征对于鉴别急、慢性排异具有重要意义。Objective To study the clinical evidences and pathological changes of acute and ceronic rejection after liver transplantation. Methods Two cases of acute and/or chronic rejection after orthotopic livertransplantation in our hospital were observed. The laboratory tests and histopathological features were also analysed. Results in acute rejection, AST and ALT were significantly increased, however, the TBIL was relativelylew. The pathological examination showed three main features. In chronic rejection, TBIL increased evidentlywhile the levels of AST and ALT were coparatively low, and two main features of patological changes wereshowed. Conclusions The laboratory tests and the pathological features are important in distinguishing acute fromchronic rejection after liver transplantation.

关 键 词：肝移植 病理学 排异反应 

分 类 号：R657.305[医药卫生—外科学] R392.4[医药卫生—临床医学]