冬虫夏草钙制剂对衰老小鼠的抗衰老和免疫调节作用  

Effects of Calcium agent from cultured Cordyceps sinensis on anti-aging and immunoregulation in mice

作　　者：胡征[1] 刘丹丹[1] 

机构地区：[1]湖北工业大学生物工程学院发酵工程省部共建教育部重点实验室,湖北武汉430068

出　　处：《中国老年学杂志》2010年第19期2780-2781,共2页Chinese Journal of Gerontology

基　　金：湖北省科技厅自然基金项目(No.2004ABA228)

摘　　要：目的研究冬虫夏草钙制剂对小鼠抗衰老和免疫调节作用,并探讨其作用机制。方法以D-半乳糖所致亚急性衰老小鼠为模型,测定冬虫夏草钙制剂对衰老小鼠全血丙二醛(MDA)、超氧化物歧化酶(SOD)、血清谷胱甘肽过氧化物酶(GSH-Px)及白细胞介素-1、6、8(IL-1、6、8)含量。结果①虫草组MDA含量显著低于衰老模型组和空白对照组(P<0.05),SOD及GSH-Px活性显著高于衰老模型组和空白对照组(P<0.05);②虫草组与衰老模型组比较,小鼠血清IL-1,IL-6水平无显著性变化,但IL-8水平升高,差异显著(P<0.05)。结论冬虫夏草钙制剂具备抗衰老活性和免疫活性。Objective To study anti-aging and immunoregulation effects and mechanism of calcium agent from cultured Cordyceps sinensis （CCS） on aged mice. Methods The aged mice were induced by D-galactose,they were given dose of 0.1 g/ml CCS by 0.5 ml everyday for 4 w. Then the contents of malondialdehyde （MDA） and superoxide dismutase （SOD） of blood cell and glutathione peroxidase （GSH-Px） and interleukin （IL）-1,6,8 in serum were measured. Results In the mice treated with CCS,the content of MDA was lower than those in model and blank group （P0.05）,the activity of SOD and GSH-Px were significantly increased compared with other groups （P0.05）. There were no significant difference of serum IL-1 and IL-6 among three experimental groups,but the CCS group could remarkably improve the activity of IL-8 （P0.05）. Conclusions CCS shows anti-aging and immunoregulation effects on the aged mice.

关 键 词：冬虫夏草钙制剂 抗衰老 免疫调节 

分 类 号：R285.5[医药卫生—中药学]