不动杆菌对碳青霉烯类抗生素的耐药机制和治疗进展  

Mechanisms of carbapenems resistance in acinetobacter and progress of treatment

作　　者：张维[1] 柳开忠[1] 

机构地区：[1]浙江省肿瘤医院重症监护室,浙江杭州310022

出　　处：《浙江大学学报（医学版）》2010年第5期542-547,共6页Journal of Zhejiang University(Medical Sciences)

摘　　要：不动杆菌已成为医院感染的主要致病菌。随着碳青霉烯类抗生素的广泛应用,其多重耐药菌尤其是碳青霉烯类耐药菌株的出现,给临床治疗带来了很大的难题。研究发现,不动杆菌对碳青霉烯类抗生素的耐药机制主要是灭活酶的产生,其中以染色体或质粒介导的各种碳青霉烯酶最为重要。而舒巴坦和β-内酰胺类药物合用对不动杆菌有一定的治疗协同作用。Acinetobacter has been the major pathogen of nosocomial infection.With the wide use of carbapenems,the emergence of multi-resistant isolates especially those resistant to carbapenem,brings a great problem to clinical treatment.The production of inactive enzymes is the main mechanism for antibiotic resistance,particularly the production of carbapenemases mediated by chromosome or plasmid.Combinations of β-lactam antibiotics and sulbactam may show synergism or partial synergism for acinetobacter isolates.

关 键 词：鲍氏不动杆菌/药物作用 鲍氏不动杆菌/酶学 β内酰胺酶类/遗传学 β内酰胺酶类/代谢 抗菌药/药理学 抗药性 细菌/遗传学 

分 类 号：R378.99[医药卫生—病原生物学]