慢性压力负荷性心衰大鼠心肌细胞凋亡的研究  

Study on Cardiac Myocyte Apoptosis in Rats with Pressure Overload-induced Chronic Heart Failure

作　　者：邢洪涛[1] 柏树令[2] 张丽影[1] 

机构地区：[1]沈阳医学院附属中心医院病理科,辽宁省沈阳市110024 [2]中国医科大学解剖学教研室

出　　处：《中国微循环》1999年第2期90-92,共3页Journal of Chinese Microcirculation

摘　　要：目的探讨慢性心衰时是否有心肌细胞凋亡。方法利用末端转移酶介导的切口末端标记法（ＴＵＮＥＬ）及ＴＥＭ法，检测慢性压力负荷性心衰大鼠左、右心室心肌的凋亡细胞。结果在心衰大鼠的左、右心室心肌组织中存在有凋亡的心肌细胞，而在对照组大鼠心肌组织中未见到心肌细胞调亡。结论慢性心衰与心肌凋亡之间有紧密联系。Objective To discuss the presence of apoptosis during chronic heart failure.Methods left and right ventricular myocardium of rats with chronic heart failure was used to study apoptosis by TUNEL and TEM methods. Results Apoptosis was detected in the myocardium of failing hearts of rats. No apoptosis was found in myocardium of rats in control group.Conclusion There exists close relationship between apoptosis and chronic heart failure.

关 键 词：细胞凋亡 慢性 心力衰竭 压力负荷性 

分 类 号：R541.602[医药卫生—心血管疾病]