阿西美辛果胶铋凝胶微丸的制备及体外释放  

Preparation and in vitro release characterization of acemetacin-loaded bismuth pectin gel beads

作　　者：刘文利[1,2] 张景勍[1,2] 张良珂[1,2] 蒋慧明[1,2] 张佩瑜[1] 

机构地区：[1]重庆医科大学生命科学院药学院,重庆400016 [2]重庆医科大学高校药物工程研究中心,重庆400016

出　　处：《中国医院药学杂志》2010年第19期1630-1634,共5页Chinese Journal of Hospital Pharmacy

基　　金：重庆市科委自然科学基金项目(编号:CSTC;2008BB5397);重庆医科大学校办课题项目(编号:XBYB2007098;NSFYY200728)

摘　　要：目的:制备阿西美辛果胶铋凝胶微丸,考察果胶铋凝胶微丸的溶胀及释药性质。方法:采用滴制法制备阿西美辛果胶铋凝胶微丸,考察其在不同介质中的溶胀特性,并考察果胶浓度,铋离子浓度,投药量对药物释放影响。结果:果胶铋凝胶微丸的溶胀具有pH依赖性。果胶浓度,铋离子浓度,投药量增加,药物释放速率有所减慢。结论:阿西美辛果胶铋凝胶微丸具有良好的缓释作用,有望成为一种新型的药物缓释载体。OBJECTIVE To prepare acemetacinqoaded bismuth pectin gel beads and investigate swelling degree and release properties. METHODS Acemetacin-loaded bismuth pectin gel beads were prepared by dropping method. Swelling properties were investigated,and the effects of several factors such as the concentration of pectin and bismuth ion, drug loading on drug release were studied. RESULTS Swelling properties of bismuth pectin gel beads were pH-dependence. Increasing the concentration of pectin or bismuth ion,drug loading, the rate of drug release decreased. CONCLUSION Acemetacin-loaded bismuth pectin gel beads show good sustained-release properties, which are potential drugs vehicle.

关 键 词：果胶铋 阿西美辛 凝胶微丸 缓释制剂 

分 类 号：R943[医药卫生—药剂学]