基于光学相干层析成像技术的光老化皮肤嫩肤实验观察  

Monitoring of Rejuvenation of Photoaged Mouse Skin Irradiated by Intense Plused Light Based on Optical Coherence Tomography

作　　者：章小曼[1,2,3] 李晖[1,2,3] 吴淑莲[1,2,3] 

机构地区：[1]福建师范大学医学光电科学与技术教育部重点实验室,福建福州350007 [2]福建师范大学福建省光子技术重点实验室,福建福州350007 [3]福建师范大学物理与光电信息科技学院,福建福州350007

出　　处：《激光与光电子学进展》2010年第10期108-112,共5页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(60578056);教育部优秀青年教师资助计划(BD0050);福建省教育厅项目(JB09072)资助课题

摘　　要：利用光学相干层析成像(OCT)技术监测了活体小鼠光老化皮肤的嫩肤效果。利用强脉冲光(IPL)照射经过紫外线诱导后的光老化皮肤,采用OCT观察该皮肤,得到不同能量密度IPL作用前后的光老化皮肤光衰减系数的变化情况,用来判断光老化皮肤的光热损伤程度及修复过程。结果表明,IPL能对光老化皮肤进行有效的嫩肤治疗;OCT是活体监测生物组织胶原修复情况的有力工具。The optical coherence tomography（OCT）technology is used to monitor the treatment of photoaged mouse skin,which is irradiated by intense plused light（IPL）.A photoaged mouse skin irradiated by ultraviolet,is treated by IPL.The OCT technology is used to observe the process of the collagen remodeling in dermis.The change of optical characteristic parameter such as attenuation coefficient during the skin rejunvenation is gotten,and the magnitude of optical-thermal damage based on the changes of optical parameter is estimated.The results indicate that IPL can be used for symptoms of photoaged skin as a nonablative method,and OCT has potential as a method for characterization of collagen remodling in vivo in clinic.

关 键 词：医用光学 光子嫩肤 胶原修复 衰减系数 光学相干层析成像 光老化 

分 类 号：R318.51[医药卫生—生物医学工程]