活血溶栓丸质量控制方法研究  

Quality Control Method of Huoxue Rongshuan Pills

作　　者：余卫兵[1] 刘红[2] 景金柱[3] 付乃华 赵连兴[1] 

机构地区：[1]河北省邯郸市药品检验所,邯郸056001 [2]邯郸市第一医院 [3]邯郸康业制药有限公司

出　　处：《中国药事》2010年第10期991-994,共4页Chinese Pharmaceutical Affairs

摘　　要：目的制定活血溶栓丸的质量控制方法。方法采用TLC法对制剂中的丹参、甘草、川芎进行鉴别,采用HPLC法测定制剂中丹参酮ⅡA、甘草酸的含量。结果各品种的薄层色谱特征明显,专属性强;丹参酮ⅡA进样量在0.0202～0.2020μg范围内与峰面积呈良好的线性关系(r=0.9999),平均回收率为99.71%,RSD为0.94%(n=6);甘草酸进样量在0.4907～5.889μg范围内呈现良好的线性关系,r=0.9999(n=6),平均回收率为99.55%,RSD为0.24%(n=6)。结论所建立的方法简便、快捷、准确,能有效地控制该制剂的质量。Objective To establish a method for quality control of Huoxue Rongshuan Pills.Methods Salvia,licorice root and Chuan Xiong were indentified by TLC.A HPLC method was established for the determination of tanshinoneⅡA and glycyrrhizic acid in Huoxue Rongshuan Pills.Results They could be identified by TLC.Tanshinone ⅡA showed a good linear relationship at a rang of 0.0202～0.2020μg（r=0.9999）.The average recovery was 99.71%,RSD=0.94%（n=6）.Glycyrrhizic acid showed a good linear relationship at a rang of 0.4907～5.889μg（r=0.9999）.The average recovery was 99.81%,RSD=0.47%（n=6）.Conclusion The method is simple,rapid and accurate.It can be used for quality control of Huoxue Rongshuan Pills.

关 键 词：活血溶栓丸 TLC HPLC 丹参酮ⅡA 甘草酸 

分 类 号：R943.3[医药卫生—药剂学]