内脏高敏感治疗药物研发进展  

Progress in novel drugs in the treatment of visceral hypersensitivity

作　　者：魏磊[1] 高峻[1] 许国铭[1] 

机构地区：[1]上海市长海医院消化内科,上海200433

出　　处：《中国新药杂志》2010年第19期1758-1761,共4页Chinese Journal of New Drugs

基　　金：国家自然科学基金(30700359);"十一五"全军医药卫生科研基金课题(国际合作06H015)

摘　　要：内脏高敏感是肠易激综合征等功能性胃肠病的重要病理生理改变。由于内脏痛觉高敏感发生机制复杂,包括外周和中枢多个因素的作用,给临床治疗带来了困难。目前临床尚没有通过直接抑制内脏痛觉治疗功能性胃肠病的药物。本文主要从受体水平综述近年来抑制内脏痛觉药物的研究进展。Visceral hypersensitivity is an important characteristic of the functional bowel disorders such as irritable bowel syndrome.The mechanism of visceral hypersensitivity is complex and unclear now.Both peripheral and central receptors are thought to contribute to the hypersensitivity.It is difficult to clinically treat visceral hypersensitivity.Yet at present functional gastrointestinal disease can not be treated with drugs directly inhibiting visceral pain clinically.This paper reviewed the progress in studies of high-sensitive receptors in the treatment of visceral hypersensitivity in recent years.

关 键 词：内脏痛高敏感 镇痛药物 受体 

分 类 号：R975[医药卫生—药品]