椎管内阻滞镇静作用的研究进展  

An advance in the study on sedation of neuraxial blockade

作　　者：马汉祥[1] 马妮娜[1] 张宁[1] 毛晶晶[1] 

机构地区：[1]宁夏医科大学附属医院麻醉科,银川750004

出　　处：《国际麻醉学与复苏杂志》2010年第5期466-469,共4页International Journal of Anesthesiology and Resuscitation

基　　金：宁夏自然科学基金项目（NZ08114）;宁夏医学院特殊人才启动项目（XT200718）

摘　　要：椎管内麻醉复合全麻作为一项麻醉技术具有诸多优点而被广泛认可和采用，而在临床麻醉中，有些患者接受椎管内麻醉后就表现有一定的镇静作用。近年来一些动物实验和临床研究均发现椎管内麻醉能够显著减少镇静药物的需要量或直接降低脑电双频指数（bispectral index，BIs）值和OAA／S评分，提示椎管内阻滞具有直接或间接的镇静作用。目前普遍认为可能的机制为去传人理论，即局麻药阻断了局部的传人信号，降低了对脑干网状结构上行激活系统的刺激，从而产生相应的镇静作用。Neuraxial blockade combined with general anesthesia is commonly used in clinical anesthesia because of advantages of combined anesthesia. Several studies have reported that spinal anesthesia and epidural anesthesia appear to have sedative effect, and local anesthetics used for neuraxial blockade could reduce the dosage of sedative or decrease BIS and OAA/S score directly in animal experiments and clinical trials. The main mechanism of this phenomenon is considered to be de-afferentation.

关 键 词：椎管内麻醉 镇静 机制 

分 类 号：R614[医药卫生—麻醉学]