药物性肾损伤机制研究进展  

Progress of the study of mechanism on drug induced kidney injury

作　　者：薛翔[1] 宫丽崑 任进[1] 

机构地区：[1]中国科学院上海生命科学院上海药物研究所新药研究国家重点实验室,上海201203

出　　处：《药学学报》2010年第10期1199-1204,共6页Acta Pharmaceutica Sinica

基　　金：国家科技重大专项“重大新药创制”(2008ZX09305-007;2009ZX09501-033)

摘　　要：药物性肾损伤在新药开发过程和临床用药中十分常见, 许多药物可引起不同程度的肾脏损伤, 包括肾小管间质性、肾小球性和肾血管性疾病。深入研究药物性肾损害产生的分子机制, 对降低新药开发风险、临床合理用药、早期发现不良反应和采取有效防治措施均有着重要意义。Drug-induced nephrotoxicity is very common in both new drug development and clinic practice. Various drugs can induce kidney injuries, including tubulointerstitial, glomerular and renal vascular disease. To investigate the mechanism of drug induced nephrotoxicity is important for risk reduction of new drug development, reasonable drug usage, early discovery and effective prevention/treatment of adverse effects in clinics.

关 键 词：药物性肾损伤 急性肾小管坏死 小管间质性肾炎 

分 类 号：R965[医药卫生—药理学]