黄褐斑病损的组织学特征及角蛋白10的表达  

Histological features of melasma lesions and the expression of keratin 10

作　　者：唐建兵[1] 程飚[1] 张伟[2] 李勤[1] 柳大烈[1] 余文林[1] 曾东[1] 廖元兴[1] 

机构地区：[1]广州军区广州总医院整形美容外科,广东广州510010 [2]广州军区广州总医院病理科,广东广州510010

出　　处：《中国美容医学》2010年第9期1340-1342,共3页Chinese Journal of Aesthetic Medicine

基　　金：2010年中华医学会-欧莱雅中国人健康皮肤/毛发研究项目(编号:S2010070816)

摘　　要：目的:研究黄褐斑皮肤的组织学改变及角蛋白10(CK10)的表达情况。方法:取黄褐斑患者睑袋术后外眦多余皮肤,行石蜡切片的HE染色、Fontana-Masson染色和CK10的免疫组化染色,观察此处皮肤的病理学改变和CK10的分布情况。结果:黄褐斑皮损处表皮变薄,基底层细胞周围可见明显色素颗粒,基底上层、毛囊上段、真皮层也有色素颗粒分布,真皮胶原紊乱、断裂,皮肤附属器数量较少。CK10主要分布在表皮的基底上层和皮脂腺细胞的胞浆和腺泡的外层。结论:黄褐斑病损皮肤各层黑色素含量增多,皮肤组织结构多有老化表现。CK10在基底上层表达增强,其表达增强可能与表皮细胞过度分化、皮肤老化有关。Objective To investigate the histological changes of the skin with melasma and keratin 10 （CK10） expression. Methods The excess skin in the lateral canthus was acquired after eyelid plasty operation for melasma patients,the paraffin sections was stained with HE,Fontana -Masson and CK10 immunohistochemical staining to observe the pathological changes of the melasma skin and the distribution of CK10. Results The epidermis was thin in the melasma skin. And the melanin can be seen clearly around the basal layer cells.It could be seen in the upper basal layer,the upper hair follicle and dermis. Dermal collagen was disorder,fracture,the number of skin appendages was less than the normal skin. CK10 mainly distributed in the upper stratum of basal epidermis and the most outer layer of sebaceous glands. Conclusion The content of melanin increases in melasma skin,and skin aging features appear in the histological structure. CK10 expresses strongly in the upper stratum of basal epidermis which maybe relate with the excessive differentiation of epidermal cells and the skin aging.

关 键 词：黄褐斑 色素性疾病 组织结构 角蛋白10 皮肤老化 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]