不同浓度丙泊酚对危重症患者血清瘦素水平影响的研究  

Influence of Different Concentration of Propofol on the Serum Leptin Levels of Critically Ill Patients

作　　者：王云徽[1] 张玮[1] 曾伟[1] 钱传云[1] 

机构地区：[1]昆明医学院第一附属医院急诊科ICU,云南昆明650032

出　　处：《昆明医学院学报》2010年第9期13-15,共3页Journal of Kunming Medical College

基　　金：云南省自然科学基金资助项目(2008ZC120M)

摘　　要：目的比较2%丙泊酚与1%丙泊酚两者对危重症患者血清瘦素(Leptin)的影响.方法 60例APACHEⅡ评分≥16分的危重病人作为研究对象,随机分成两组,每组30人;A组输注2%丙泊酚,B组输注1%丙泊酚,用BIS监护仪控制镇静水平,Bis值控制在60到80之间,采用放射免疫法检测治疗前后血清瘦素水平,记录患者第6、12、24、48、72 h的血清瘦素值.结果 A组患者血清瘦素水平明显低于B组.结论 2%丙泊酚临床安全性明显高于1%丙泊酚.Objective To compare the effects of 2% propofol and 1% propofol on the serum leptin levels of critically ill patients.Method Sixty critical patients with APACHEⅡscale≥16 were studied.Patients were randomly divided into 2 groups：A group and B group,30 patients in each group.Patients in A group received 2%propofol and in B group received 1% propofol.The sadation level was controlled with 60 to 80 on BIS monitor.The radioimmunoassay was used to detect the serum leptin levels before and after treatment,and the serum leptin levels at the first 6,12,24,48,72 hour were recorded.Result The serum leptin levels of patients in A group were significantly lower than those in B group.Conclusion The clinical safety of 2% propofol is significantly better than 1% propofol.

关 键 词：丙泊酚 瘦素 镇静 

分 类 号：R971.3[医药卫生—药品]