丹参注射液对同种异体肌腱移植后粘连防治的实验研究  

Effect of Salvia Miltiorrhiza Injection on Adhesions after Tendon Allograft Transplantation

作　　者：吴迎波[1] 孙海军[1] 严敏 宋根套[1] 李小昌[1] 赵胡瑞 

机构地区：[1]石河子大学医学院,新疆石河子832003 [2]解放军第四七四医院,新疆乌鲁木齐830013

出　　处：《现代生物医学进展》2010年第18期3456-3459,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨局部应用丹参注射液(Salvia Miltiorrhiza,SM)对异体肌腱移植后粘连的影响。方法:使用深低温冷冻处理的同种异体肌腱修复缺损的大鼠屈趾肌腱,72只大鼠随机分为2组,A组为试验组,腱周局部注射丹参注射液,B组为对照组,注射生理盐水(Saline)。术后2、4、8周处死动物,标本进行大体观察、组织学观察及生物力学测定。结果:A组粘连范围小,粘连等级评分与B组相比有统计学意义,力学测定结果显示A组与B组无统计学意义。结论:丹参注射液能有效减轻肌腱移植后粘连。Objective：To investigate the preventing and curing tendon adhesion with salvia miltiorrhiza solution aftertendon allograft transplantation.Method：We used profound hypothermia homogeneous variant tendon graft to repair the defects of flexor tendon of rats.72 rats were divided into three groups at random.A is the experiment group：around the tendon inject with salvia miltiorrhiza solution,B is the control groups inject with Sodium Chloride.Put the animals to death in 2 weeks,4 weeks and 8 weeks post operation.Samples were undertaken general observation,histological observation and biomechanical test.Results：Compared with B group,adhesion extent and score of tendon showed a significant difference（P0.05）in A group.Biomechanical test shows there is no significant deviation in two groups.Conclusion：Topical injection of salvia miltiorrhiza solution can lessen adhesion of tendon graft.

关 键 词：丹参 异体肌腱 移植 粘连 

分 类 号：Q95-3[生物学—动物学] R685.6[医药卫生—骨科学]