脂肪乳剂理化性质和稳定性的影响因素浅析  

Approach of Factors Influencing Physico-chemical Property and Stability of Lipid Emulsions

作　　者：张小娟[1] 李竹雯[1] 李树[2] 梅兴国[3] 

机构地区：[1]中国药科大学高职学院,江苏南京211198 [2]军事医学科学院放射与辐射医学研究所,北京100850 [3]军事医学科学院毒物药物研究所,北京100850

出　　处：《现代生物医学进展》2010年第18期3581-3584,共4页Progress in Modern Biomedicine

摘　　要：静脉注射脂肪乳剂是由两种互不相溶的液体(油相和水相)混合而成,是水不溶性药物的良好载体,可以提高易水解药物的稳定性并且减少各种毒副作用。脂肪乳剂属于热力学不稳定体系,其会表现出各种不稳定的现象如聚集,絮凝,聚结等,最终可能出现相分离。本文就处方、工艺及包装等影响脂肪乳剂理化性质及稳定性的主要因素进行综述。Lipid injectable emulsions are dispersions of two immiscible liquids（oil phase and water phase）,they incorporate water non-soluble drugs,stabilize drugs which tend to undergo hydrolysis and reduce side effects of various potent drugs.They require energy to be formed,and are thermodynamically unstable.They are subjected to various instable processes like aggregation,flocculation,coalescence and hence eventual phase separation.This paper gave review on the formulation,preparation and package,etc,some main influencing factors of the physico-chemical property and stability of lipid emulsions.

关 键 词：脂肪乳 亚微乳 粒径 稳定性 

分 类 号：R944[医药卫生—药剂学]