恶性肿瘤与Rh血型系统各表型的相关性分析  

Correlation analysis between Rh blood group phenotypes and malignant tumors

作　　者：马现君[1] 楚中华[1] 曹秀玲[2] 高海燕[1] 李伟[1] 孔燕[1] 李德鲁[1] 

机构地区：[1]山东大学齐鲁医院输血科,济南250012 [2]山东大学齐鲁医院科研处

出　　处：《临床血液学杂志（输血与检验）》2010年第4期459-460,共2页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

基　　金：山东省教育厅课题(No:J08LH61);山东省软科学研究计划项目(No:2009RKA062)

摘　　要：目的:分析恶性肿瘤患者Rh血型表型的分布特点,并与正常对照组进行比较,查找恶性肿瘤与Rh血型表型相关性。方法:对120例恶性肿瘤患者(患者组)及100例正常健康人群(对照组)进行Rh血型表型测定,对其表型分布进行统计分析,采用χ2检验和相对危险度OR值来估计相对危险性。结果:恶性肿瘤患者组与对照组Rh血型表型CcDEe分布之间的差异有统计学意义(χ2=4.51,P<0.05)。恶性肿瘤患者组Rh血型表型分布从高到低分别是CcDEe54例(45.00%),CCDee39例(32.50%),CcDee14例(11.67%),ccDEE9例(7.50%),ccDEe3例(2.50%),CCDEe1例(0.83%);对照组Rh血型表型分布从高到低分别是CCDee47例(47.00%),CcDEe32例(32.00%),ccDEE9例(9.00%),CcDee6例(6.00%),ccDEe5例(5.00%),CCDEe1例(1.00%);结论:恶性肿瘤的发生与Rh血型表型的分布有关,CcDEe(OR=1.82)、CcDee(OR=2.07)表型发病率明显高于其他表型。Objective：To investigate the correlation between Rh blood group phenotypes and malignant tumors.Method：Rh blood group phenotypes of 120 patients with malignant tumor and 100 healthy people were analyzed and analyzed by Chi-square test and relative risk OR value in order to estimate the relative risk. Rsullt：The distribution of Rh blood group phenotypes between patients and controls had a significant difference （χ2=4.51; P0.05）. The Rh blood group phenotype distribution of patients from high to low in turn was as followings：CcDEe （54 case 45.00%）,CCDee （39 case 32.50%）,CcDee （14 case 11.67%）,ccDEE （9 case 7.50%）,ccDEe （3 case 2.50%） and CCDEe （1 case 0.83%）. While in controls was CCDee （47 case 47.00%）,CcDEe （32 case 32.00%）,ccDEE （9 case 9.00%）,CcDee （6 case 6.00%）,ccDEe （5 case 5.00%） and CCDEe （1 case 1.00%）. The persons who had Rh blood group phenotype of CcDEe （OR=1.82） and CcDee （OR=2.07） were liable to have tumors. Conclusion：There might be a certain correlation between malignant tumors and Rh blood group phenotype distribution,and the persons who had Rh blood group phenotype of CcDEe and CcDee were liable to have tumors.

关 键 词：恶性肿瘤 Rh血型表型 相关性分析 

分 类 号：R273[医药卫生—中西医结合]