IRF5 rs2004640基因多态性与系统性红斑狼疮的相关性研究  

Study on relationship between polymorphism site rs2004640 of IRF5 and SLE patients

作　　者：张旋 殷晓婕[2] 宋卫青[2] 李化会[2] 陈华波[2] 原江水[2] 

机构地区：[1]青岛卫生学校,山东青岛266011 [2]青岛市市立医院检验科

出　　处：《临床血液学杂志（输血与检验）》2010年第4期467-469,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:研究山东地区汉族人群干扰素调节因子5(IRF5)基因rs2004640单核苷酸多态性,探讨其与系统性红斑狼疮(SLE)易感性之间的关系。方法:采用聚合酶链反应和限制性片段长度多态性等方法对92例SLE患者和88例健康对照IRF5基因rs2004640G/T多态性进行分析,计算基因型和等位基因频率。结果:SLE患者IRF5rs2004640GG、GT、TT基因型频率分别是0.198、0.521和0.281,与对照组比较差异有统计学意义(χ2=8.73,P<0.05);SLE患者IRF5rs2004640T、G等位基因的频率分别为0.402、0.598,与对照组比较差异有统计学意义(χ2=7.41,P<0.01)。结论:山东汉族人群IRF5基因位点rs2004640的多态性可能与山东地区汉族人群SLE的易感性有关。Objective：To investigate single nucleotide polymorphism of interferon regulation factor 5 （IRF5） rs2004640 and its relationship with systemic lupus erythematosus （SLE） susceptibility in a population from Shandong province.Method：The polymorphism （rs2004640G/T） was detected with polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） in 92 cases of SLE and 88 healthy controls.The genotype and allele frequencies were calculated and analyzed.Result：①The genotype frequencies of GG,GT and TT of rs2004640 in SLE were 0.198,0.521 and 0.281 respectively,which had a significant difference compared with those of controls （χ2= 8.73,P0.05）.②The allele frequencies of T and G of rs2004640 in SLE were 0.402 and 0.598 respectively,which had a significant difference compared with those of controls （χ2= 7.41,P0.01）.Conclusion：The polymorphism of IRF5 rs2004640 might be associated with SLE in the Han population from Shandong province of China.

关 键 词：系统性红斑狼疮 干扰素调节因子5 单核苷酸多态性 

分 类 号：R758.62[医药卫生—皮肤病学与性病学]