辛伐他汀对急性冠脉综合征患者血浆纤维蛋白原、D-二聚体的影响  

Influence of simvastatin on improvement of plasma Fib and D-dimer levels in patients with acute coronary syndrome

作　　者：郝明泽[1] 孙一荣[1] 王风云[1] 

机构地区：[1]聊城市第二人民医院,山东临清252601

出　　处：《心血管康复医学杂志》2010年第5期514-516,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:研究辛伐他汀对急性冠脉综合征(ACS)患者血浆纤维蛋白原(Fib)、D-二聚体水平的影响。方法:ACS患者116例,随机单盲分为辛伐他汀组58例,常规治疗组58例,另外随机选择50例正常人作为对照组。采用血凝仪法测定Fib含量,胶体金法测定D-二聚体含量。结果:ACS患者与正常对照组比较,血浆Fib[(4.92±0.65)g/L∶(2.61±0.48)g/L]、D-二聚体[(0.58±0.16)mg/L∶(0.16±0.06)mg/L]水平明显升高(P<0.01);辛伐他汀组和常规治疗组治疗前Fib、D-二聚体水平比较无显著性差异(P>0.05);辛伐他汀组治疗后Fib[(2.82±0.55)g/L∶(4.92±0.53)g/L]、D-二聚体[(0.22±0.07)mg/L∶(0.57±0.14)mg/L]水平较治疗前明显降低(P<0.01),且明显低于常规治疗组治疗后[Fib(4.86±0.56)g/L,D-二聚体(0.53±0.12)mg/L]水平(P<0.01),而常规治疗组治疗前、后Fib、D-二聚体水平无明显变化(P>0.05)。结论:辛伐他汀可通过降低急性冠脉综合征患者纤维蛋白原、D-二聚体水平,改善血液流变学状态,从而改善心肌供血,延缓冠心病的发生、发展过程。Objective： To assess the effects of simvastatin on plasma fibrinogen （Fib） and D--dimer levels in patients with acute coronary syndrome （ACS）. Methods： A total of 116 patients with ACS were randomly divided into receive simvastatin plus conventional treatment （simvastatin group, n = 58） or conventional treatment alone （conventional group, n= 58）. Additional 50 healthy adults were recruited as normal control group. The plasma Fib levels were moni- tored using an automated coagulometer method. The plasma D--dimer levels were monitored using an colloidal gold method. Results： The plasma Fib and D--dimer levels in patients with ACS were significantly higher than those of the normal control group [Fib （4.92±0.65） g/L vs. （2.61±0.48） g/L, D--dimer （0.58 0.16） mg/L vs. （0.16±0.06） mg/L, P〈0.01 all]. Compared to pre-treatment, the simvastatin group patients experienced a significant reduction of the plasma Fib and D--dimer levels after treatment [Fib （4. 92±0.53） g/L vs. （2.82±0. 55） g/L, D--all- met （0. 57±0.14） mg/L vs. （0.22±0.07） rag/L, P〈0.01 all], They were significantly lower than those of con- ventional group after treatment I-Fib （4. 86±0.56） g/L, D--dimer （0. 53±0.12） mg/L, P〈0.01 all]. The patients of conventional group showed no significant difference of plasma Fib and D--dimer levels before and after treatment （P 〉0.05）. Conclusion： Simvastatin can improve the blood supply to cardiac muscles and prognosis of coronary heart dis- ease by reducing plasma Fib and D--dimer levels.

关 键 词：辛伐他汀 冠状动脉疾病 纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]