光化学诱导树鼠句血栓性局部脑缺血及其对脑-心卒中的影响  

Effect of Monoamine Neurotransmitters on Brain Edema and Cerebral Cardiac Stroke Following Photochemically Induced Thrombotic Cerebral Ischemia in Tree Shrews

作　　者：李树清[1] 孟强[1] 

机构地区：[1]昆明医学院病理生理教研室,昆明650031

出　　处：《微循环学杂志》1999年第2期3-5,共3页Chinese Journal of Microcirculation

基　　金：国家自然科学基金;卫生部 科研基金

摘　　要：Objective: To investigate the relationship between the monoamine neurotransmitters and cerebral cardiac stroke after photochemical reaction. Method: An animal model of photochemically induced thrombotic focal ischemia in tree shrews were produced by radiating the right skull. The measurements of monoamine neurotransmitters in cortex and plasma and of brain water contents were performed. Results: Norpinephrine(NE), dopamine(DA), and serotonine(5 HT) decreased markedly, but 5 hydroxyindole 3 acetic(5 HIAA) acid increased gradually with the ischemic time( P < 0.01 ). The brain water content was higher than that of the control( P < 0.01 ). Moreover, plasma NE increased during 24 hours but decreased at 72 hours after photochemical reaction( P < 0.01 ). Conclusion: The monoamine neurotransmitters could enhance cerebral vascular permeability, promote the formation of brain edema and contribute to the pathogenesis of cerebral carding stroke after cerebral ischemia.Objective: To investigate the relationship between the monoamine neurotransmitters and cerebral cardiac stroke after photochemical reaction. Method: An animal model of photochemically induced thrombotic focal ischemia in tree shrews were produced by radiating the right skull. The measurements of monoamine neurotransmitters in cortex and plasma and of brain water contents were performed. Results: Norpinephrine(NE), dopamine(DA), and serotonine(5 HT) decreased markedly, but 5 hydroxyindole 3 acetic(5 HIAA) acid increased gradually with the ischemic time( P < 0.01 ). The brain water content was higher than that of the control( P < 0.01 ). Moreover, plasma NE increased during 24 hours but decreased at 72 hours after photochemical reaction( P < 0.01 ). Conclusion: The monoamine neurotransmitters could enhance cerebral vascular permeability, promote the formation of brain edema and contribute to the pathogenesis of cerebral carding stroke after cerebral ischemia.

关 键 词：脑缺血 血栓性 光化学诱导 脑中风 心功能紊乱 

分 类 号：R255.206[医药卫生—中医内科学] R259.416[医药卫生—中医学]