网状组织工程肌腱支架增强体的降解性能  

The Degradation Property of a Netty Structure Scaffold Reinforcement for Tendon Tissue Engineering

作　　者：蔡俊瑶[1,2] 文添卉[1,2] 邓丹[3] 杨瑶斐[3] 张佩华[1,2] 陈明 

机构地区：[1]东华大学产业用纺织品教育部工程研究中心 [2]东华大学纺织学院,上海201620 [3]组织工程(上海)国家工程研究中心,上海200235 [4]上海昌杰纺织品有限公司,上海201620

出　　处：《东华大学学报（自然科学版）》2010年第5期491-495,562,共6页Journal of Donghua University(Natural Science)

基　　金：上海市教委科研创新项目(08ZZ32);高等学校学科创新引智计划(B07024)

摘　　要：以聚乙醇酸(Polyglycolic Acid,PGA)纤维和聚乳酸(Polylactic Acid,PLA)纤维为原料,用编织的方法制成一种网状圆筒形组织工程肌腱支架的增强体,探讨不同孔径支架增强体在体外降解过程中的断裂现象、拉伸强力、断裂伸长、质量衰变特征.得出组织工程肌腱支架增强体的拉伸断裂规律,孔径大小对支架增强体在降解过程中的强力、伸长和质量衰减性能影响不大.将支架增强体与PGA纤维复合构成组织工程肌腱支架,并在其上种植皮肤成纤维细胞.试验结果显示孔径大小对组织工程肌腱支架的力学性质有较大影响,其生物相容性良好.A netty structure was made for reinforcing body of tendon scaffold tissue engineering, using polyglycolic acid（PGA） and polylactic acid（PLA） fibers. Each sample of different pore sizes was investigated on its form of tensile breaking, the change of strength and elongation as well as the mass decay characteristics during the degradation. The results showed the regular pattern of tensile rupture of the scaffold and indicated that the net size did not have much effect on the scaffold＇s strength, elongation and mass attenuation. PGA fibers were filled into the netty reinforcing body to form a tissue engineering tendon scaffold which was subjected to the dermal fibroblasts experiment. The results showed that net size had much effect on mechanical properties of the scaffold, besides, all samples presented a favorable cellular responses.

关 键 词：网状 肌腱 支架 降解 性能 

分 类 号：TS106.67[轻工技术与工程—纺织工程]