100例大鼠原位肝移植  

ONE HUNDRRD ORTHOTOPIC LIVER TRANSPLANTATIONS IN RATS

作　　者：胡浩[1] 陈易人[1] 李纲[1] 钱海鑫[1] 沈振亚[1] 秦磊 

机构地区：[1]苏州医学院附属第一医院

出　　处：《肝胆外科杂志》1999年第3期225-226,共2页Journal of Hepatobiliary Surgery

摘　　要：目的防止大鼠原位肝移植术后肝上下腔静脉吻合口撕裂出血，减少受体血管重建后吻合口远侧已形成血栓引起的肝坏死、下肢瘫痪和肺栓塞等严重并发症。方法参照Ｋａｍａｄａ介绍的方法，着重对肝上下腔静脉、门静脉和肝下下腔静脉吻合方法作了进一步改进。结果供肝热缺血时间２．５～３．５分钟，平均３．０分钟，安装袖套管时间约２．０分钟，肝上下腔静脉吻合时间平均为８．５分钟，供肝冷缺血时间２３．０～３０．５分钟，无肝期９．０～１２．０分钟，１周存活率８８％。结论改进的血管吻合方法提高了手术成功率。Objective To prevent SHVC anastomotic site from laceration and decrease severe complications such as liver necrosis,hind limb paralysis and pulmonary embolism caused by thrombosis preformed at anastomotic stoma after recipient's vascular reconstruction. Methods Based on Kamada's method,we modified the anastomoses of suprahepatic vena cava,portal vein and infrahepaticvena cava. ResultsThe anhepatic period was 912 min,and the warm and cold ischemic time was 2.53.5 min and 23.030.5 min respectively.88% of the grafted animals survived for 1 week.Conclusion This led to an increased operation successful rate in orthotopic liver transplantation in the rat.

关 键 词：肝移植 模型 技术 

分 类 号：R657.305[医药卫生—外科学]