成人斯蒂尔病与不明原因发热临床分析  

A clinical study of Still's disease in adults with fever of unknown origin

作　　者：马锦玲[1] 曹剑[1] 钱远宇[1] 郭园园[1] 孟庆义[1] 

机构地区：[1]解放军总医院南楼心脏监护室,北京100853

出　　处：《武警医学》2010年第10期866-868,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨不明原因发热(fever of unknown origin,FUO)中成人斯蒂尔病(adult—onset Still's disease,AOSD)的临床特征,以提高对本病的认识和诊断水平。方法回顾性分析解放军总医院2000-01至2007-12间689例FUO患者中127例AOSD的临床表现、辅助检查,并与FUO中感染性疾病等进行对比分析。结果 (1)本组FUO中AOSD在结缔组织病中所占比例最高53.8%(127/236);(2)关节痛、皮疹、咽痛、肌痛、肝酶、C-反应蛋白、血清铁蛋白增高的比例均高于感染性疾病组,差异有统计学意义(P均<0.05)。结论 AOSD是FUO中的一个常见病因,在FUO中出现关节痛、皮疹、咽痛、肌痛、肝酶、C-反应蛋白、乳酸脱氢酶、血清铁蛋白增高应高度怀疑有此病。Objective To study the clinical features of Still＇s disease （AOSD） in adult patients of with fever unknown origin （FUO） , in order to improve diagnosis. Methods The clinical manifestations and laboratory finolings of 127 AOSD patients among the total of 689 FUO eases were analyzed and compared with infected cases. Results （ 1 ） AOSD was the most common connective tissue disease （53.8% , 127/236） in FUO. （2） The percentage of arthralgia, rash, sore throat, myalgia , increased serum hepatic enzymes and CRP levels in AOSD was significantly higher than those in the infected cases （ all P 〈 0.05 ）. Conclusion AOSD is the most common disease in FUO. FUO patient with symptoms of arthralgia, rash, sore throat, myalgia , increased serum hepatic enzymes, CRP and LDH levels should he considered to have been afflicted with AOSD.

关 键 词：成人斯蒂尔病 不明原因发热 结缔组织病 感染性疾病 

分 类 号：R593.22[医药卫生—内科学]