CAR在病毒性心肌炎和扩张型心肌病心肌中的表达  

Expression of CAR in Myocardial of Viral Myocarditis and Dilated Cardiomyopathy

作　　者：许弘飞[1,2] 陈建雷 达徐平[1] 吴克荣[1] 刘国庆[1] 赵子琴[2] 韩新华[1] 

机构地区：[1]南通大学医学院法医学教研室,江苏南通226001 [2]复旦大学上海医学院法医学系,上海200222 [3]启东市公安局刑警大队,江苏启东226200

出　　处：《法医学杂志》2010年第5期328-331,共4页Journal of Forensic Medicine

摘　　要：目的探讨病毒性心肌炎(viral myocarditis,VMC)和扩张型心肌病(dilated cardiomyopathy,DCM)的发病机制及相互关系,从而提高心源性猝死法医学鉴定的可靠性和准确性。方法对VMC组22例、DCM组20例和对照组16例的心肌组织中柯萨奇-腺病毒受体(coxsackie-adenovirus receptor,CAR)的表达进行改良的免疫组织化学研究。结果 VMC组和DCM组心肌组织细胞膜呈现深棕黄色阳性颗粒,有较高水平的CAR表达,与对照组比较,差异有统计学意义(P<0.05),对照组染色阴性。结论 VMC和DCM组心肌中CAR的高表达,提示VMC和DCM的发病机制可能与病毒感染有关,病毒感染并破坏心肌细胞导致心肌细胞坏死,心功能受损,使VMC进展为DCM。Objective In order to improve accuracy and reliability of forensic diagnosis of sudden cardiac death,pathogenesis and relationship between the viral myocarditis（VMC） and dilated cardiomyopathy（DCM） were investigated.Methods Improved immunohistochemical technique was used to detect the expression of the CAR in myocardium samples,including 22 deceased with VMC,20 deceased with DCM and 16 control deceased.Results The brown staining on the cell membrane of myocardium showed positive result.There was a prominent CAR expression in VMC group and DCM group,which were statistically significant difference compared with control group（P0.05）.Conclusion The CAR expression showed significantly higher in VMC and DCM groups.The viral infection can result in myocardial necrosis and impaired cardiac functions.These abnormalities can trigger a cascade of events that contributed to the progress of VMC to DCM.

关 键 词：法医病理学 猝死 心脏 心肌病 扩张型 病毒性心肌炎 柯萨奇-腺病毒受体 

分 类 号：R542.2[医药卫生—心血管疾病]