血清胱抑素C与^(99m)Tc-DTPA GFR测定在2型糖尿病肾病中的对比研究  

The Comparative Study of the Measurement of Serum Cystatin C and ^(99m)Tc-DTPA for the Measurement of Glomerular Filtration Rate (GFR) in Type 2 Diabetic Nephropathy

作　　者：孔令华[1] 王雪芹[2] 吴俊渊[3] 顾凯凯[1] 高彬[1] 

机构地区：[1]南通大学第二附属医院核医学科,江苏南通226001 [2]南通大学第二附属医院内分泌科,江苏南通226001 [3]南通大学第二附属医院检验科,江苏南通226001

出　　处：《标记免疫分析与临床》2010年第5期300-302,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨血清胱抑素C(Cys C)测定与99mTc-二乙三胺五乙酸(99mTc-DTPA)测定血浆肾小球滤过率(GFR)用于2型糖尿病(T2DM)早期肾功能损害检测的临床意义。对87例T2DM患者分别采用免疫比浊法测定Cys C和肾动态显像测定GFR。结果显示,T2DM组血清Cys C为1.68±0.52mg/L,正常对照组为0.72±0.26 mg/L,T2DM组GFR为93.82±30.25mL/min/1.73m2,正常对照组GFR为107.48±15.23 mL/min/1.73m2,两组间比较差异有统计学意义(P<0.01)。T2DM组的Cys C与GFR呈负相关(r=-0.38),Cys C随着GFR的下降而升高,差异有统计学意义(P<0.01)。结论:Cys C能反映T2DM患者早期肾功能的损害,免疫比浊方法简便,结果准确,易于推广;肾动态显像GFR测定方法稍复杂,需要专门设备,重复性稍差,但能反映各分肾功能。先用比浊法测定Cys C后再用肾动态显像测定GFR,两者有机结合对早期监测T2DM患者的早期肾功能具有重要意义。To explore the clinical value between measurement of serum cystatin C（Cys C） and determination of plasma with 99mTc-DTPA glomerular filtration rate（GFR） clearance for type 2 diabetes（T2DM） in early detection of renal damage,the serum cystatin C levels in 87 patients with type 2 diabetes were determined by immune turbidimetry Cys C.The patients were also carried out dynamic imaging to measure renal GFR.The result showed that the serum levels of Cys C in patients with Type 2 diabetic was 1.68 ± 0.52mg / L,the normal group was 0.72±0.26 mg/L;The GFR in patients with T2DM was 93.8 ± 30.2ml/min/1.73m2,the control group was 107.48±15.23 ml/min/1.73m2,there was significant difference between patients and controls（P0.01）.There was a negatively correlation between serum Cys C and 99mTc-DTPA renal dynamic imaging.The serum Cys C could reflect the damage in early diabetic patients.The method is simple,accurate and easy to spread.The renal dynamic imaging method of GFR determination is slightly complex and requires specialized equipment.It can reflect the sub-renal function.The combined measurement of serum Cys C and GFR are very important in the early detection of type 2 diabetic patients with early renal function.

关 键 词：胱抑素C 糖尿病肾病 肾小球滤过率 肾动态显像 99mTc-二乙三胺五乙酸 

分 类 号：R587.2[医药卫生—内分泌]