2型糖尿病患者血清LDL亚组份与微量白蛋白尿的相关性  

The Relationship Between LDL Subfractions and UAER in Type-2 Diabetes Patients

作　　者：殳雪怡[1] 杨永年[1] 石凤英[1] 张忆文 吴丹[1] 

机构地区：[1]上海医科大学中山医院内分泌科,200032

出　　处：《中国临床医学》1999年第2期130-132,共3页Chinese Journal of Clinical Medicine

摘　　要：目的：探讨2型糖尿病患者LDL亚组份改变与糖尿病肾病及其血管病变的关系。方法：用非变性梯度凝胶电泳法，测定54例2型糖尿病患者血清LDL亚组份与UANR，比较不同UAER的2型糖尿病患者的LDL亚组份变化。结果：伴微量白蛋白尿2型糖尿病患者血清LDL亚组份以小颗粒LDL者较多（19/24比6/30，P＜0.0001），小颗粒LDL和UAER及ACR有显著相关性。讨论：2型糖尿病肾病患者血清中主要含有小颗粒的LDL，是2型糖尿病肾病患者心血管病变的发生率和死亡率增高的重要原因之一。Abjective: To assess the relationship between LDL subfractions and UAER in type - 2 diabetes patients. Methods: Serum LDL subfractions of 54 patients with type - 2 diabetes were measured by nondenaturing gradient gel eletroophoresis (GGE), TG, TC, Lp(a), LDL, HDL and UAER were also measured. Results: Of 24 patients with microalbuminuria, 19 had small LDL (particle size less than 25. 5 nm) were compared with only 6 of 30 patients with normal albuminuria (P < 0.0001). LDL particle size were closely correlated to UAER. Conclusions: More number of patients had small LDL in type - 2 diabetes patients with microalbuminuria compared with those without microalbuminuria. Small LDL may play a role for the high incidence of cardiovascular complications in type - 2 diabetes patients with diabetic nephropathy.

关 键 词：2型糖尿病 尿白蛋白排泄率 低密度脂蛋白亚组份 

分 类 号：R692.02[医药卫生—泌尿科学] R587.2[医药卫生—外科学]