血停跳液中最适钙离子浓度的实验研究  

Experimental Study on the Optimal Calcium Content for the Blood Cardioplegic Solution

作　　者：金光春[1] 崔苍海[1] 金基焕[1] 李香善[1] 宋伟[1] 

机构地区：[1]延边大学医学院附属医院

出　　处：《中国医师杂志》1999年第7期20-22,共3页Journal of Chinese Physician

摘　　要：本文采用离体兔心灌注模型，观察用不同Ｃａ２＋浓度的血停跳液（０７、０８、０９、１０、１１、１２、１３ｍｍｏｌ／Ｌ）灌注心脏后的心肌保护效果。结果发现Ｃａ２＋浓度为１１ｍｍｏｌ／Ｌ和１２ｍｍｏｌ／Ｌ的停跳液组，其心肌含水量、线粒体钙含量明显低于其它各组（Ｐ＜００１），超微结构损伤最轻。说明在低温状态下，血停跳液中Ｃａ２＋浓度１１～１２ｍｍｏｌ／Ｌ为最适合的。The present paper has shown the effects of myocardial protection of isolated working rabbit hearts model,which were infused by blood cardioplegic solution with different calcium contents.Fourty-nine rabbits(2 5～3 0kg) were randomly divided into 7 groups.After 60 minutes period of the hypothermic ischemic arrested hearts were infused by blood cardioplegic solution with various Ca 2+ concentration(0 7、0 8、0 9、1 0、1 1、1 2、1 3mmol/L),respectively.after 60min infusion and 30min reperfusion the water content of the myocardium,calcium content of the mitochondria and the myocardial ultrastructure were observed. The results indicate that water content of the myocardium and calcium content of mitochondria in 1.1mmol/L～1 2mmol/L groups were significantly lower than in the other groups (All P <0 05),and the myocardial ultrastructure were protected best.This study suggests that under hypothermic condition,a calcium concentration of 1 1mmol/L～1 2mmol/L is optimal for the blood cardioplegic solution.

关 键 词：血停跳液 钙离子浓度 心肌含水量 线粒体 

分 类 号：R654.1[医药卫生—外科学]