对羟基苯乙酮降血脂作用的研究  

Effect of p-hydroxyacetophenone on lowering blood lipids

作　　者：张瑱[1] 贺兴冬[1] 季申[2] 肖璘[1] 徐智儒[1] 张荣华[3] 刘全海[1] 秦燕[1] 

机构地区：[1]上海医药工业研究院药理室,上海200437 [2]上海市食品药品检验所,上海201203 [3]同济大学化学系,上海200092

出　　处：《世界临床药物》2010年第10期599-602,共4页World Clinical Drug

基　　金：上海市科委2006年度"登山行动计划"项目(编号:06DZ19007)

摘　　要：目的考察茵陈有效单体对羟基苯乙酮的降血脂作用。方法建立SD大鼠高血脂模型,以大鼠血清总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平为疗效评价指标,观察对羟基苯乙酮的降血脂效应,并与辛伐他汀及对羟基苯乙酮衍生物相比。结果对羟基苯乙酮可降低高脂血症模型大鼠血清TC和LDL-C水平;病理切片显示其对模型大鼠的脂肪肝改善有一定益处。结论对羟基苯乙酮可能是茵陈等具降脂作用中药的有效成分。Objective To observe the effect of p-hydroxyacetophenone, an effective monomer of Artemisiae capillaris, on lowering blood lipids. Methods Hyperlipemia models were established in SD rats. The effect of p-hydroxyacetophenone on lowering blood lipids was evaluated by the level of serum total cholesterol（TC） and low density lipoprotein cholesterol（LDL-C）, and was compared with simvastatin and derivatives of p-hydroxyacetophenone. Results p-Hydroxyacetophenone reduced the levels of serum TC and LDL-C in hyperlipemia model SD rats significantly. Patho-histological examination demonstrated that p-hydroxyacetophenone could improve fatty liver in model SD rats. Conclusion p-hydroxyacetophenone may be the active ingredient of Artemisiae capillaris responsible for cholesterol-lowering.

关 键 词：茵陈 对羟基苯乙酮 高脂血症 辛伐他汀 

分 类 号：R931.71[医药卫生—生药学] R972.6[医药卫生—药学]