苏州地区儿童血清肌酐参考值的建立  

Establishment of the reference intervals for serum creatinine concentrations of the children in Suzhou area

作　　者：薛建[1] 黄辉[1] 冯建国[1] 丁云芳[1] 

机构地区：[1]苏州大学附属儿童医院检验科,215003

出　　处：《检验医学与临床》2010年第18期1921-1922,1924,共3页Laboratory Medicine and Clinic

摘　　要：目的应用肌氨酸氧化酶法测定苏州地区健康儿童血清肌酐并建立参考值范围。方法应用酶法测定4300例健康儿童血清肌酐浓度,并按年龄和性别分组统计,以确立儿童血清肌酐的参考值范围。结果学龄期和青春期不同性别儿童的血清肌酐水平差异有统计学意义（P〈0.05）,其余各期不同性别之间差异无统计学意义。男女不同性别组各年龄期,除婴儿期与幼儿期差异无统计学意义外,其余各期之间差异均有统计学意义（P〈0.05）。各组血清肌酐参考值为新生儿期：14.4~50.0μmol/L,婴幼儿期：14.9~42.9μmol/L,学龄前期：21.1~47.9μmol/L,男性学龄期：27.1~58.3μmol/L,女性学龄期：22.2~53.4μmol/L,男性青春期：29.2~64.0μmol/L,女性青春期：24.4~58.4μmol/L。本研究的儿童各组血清肌酐参考值与其他文献报道的成人参考值差异有统计学意义。结论不同性别不同年龄的儿童血清肌酐参考值差异有统计学意义,故以后临床工作者针对这一特殊人群应建立合理的参考值范围,为临床诊断和疾病预后等提供重要依据。Objective To determine the concentration of serum creatinine from healthy children in Suzhou area by sarcosine oxidase method and to establish the pediatric reference intervals.Methods To assay the values of serum creatinine applying of enzymatic manner from the 4 300 cases of healthy children,who were divided into several groups according to the diffevent age and sex,and then the children＇s reference values of serum creatinine were established.Results The values of serum creatinine of the children with different sex in their shool age and puberty are of significant differences（P0.05）.In different groups of sex,except of the infancy and those at their toddler age,the values of other periods have obviously differences（P0.05）.And the reference intervals of every group indicated that the group of children in neonatal period is 14.4-50.0 μmol/L,infancy and toddler age group is 14.9-42.9 μmol/L,preschool age group is 21.1-47.9 μmol/L,school age of male group is 27.1-58.3μmol/L,school age of female group is 22.2-53.4 μmol/L,puberty of male group is 29.2-64.0 μmol/L,and puberty of female group is 24.4-58.4 μmol/L respectively.The reference intervals of every group in this research are different from those of adults reported by others.Conclusion In the children of different ages and sex,the reference intervals of serum creatinine are different,so we should set up a reasonable reference intervals for this special population to offer an important basis for clinical diagnosis and disease prognosis.

关 键 词：肌酐 儿童 参考值 

分 类 号：R446.1[医药卫生—诊断学]